| Gene Symbol |
ELK4
|
| Entrez Gene |
2005
|
| Alt Symbol |
SAP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ELK4, ETS-domain protein (SRF accessory protein 1)
|
| Other Description |
ETS domain-containing protein Elk-4|SAP-1|serum response factor accessory protein 1
|
| Swissprots |
P28324 P28323 Q6GSJ2
|
| Accessions |
CCV01469 CCV01470 EAW91570 EAW91571 EAW91572 EAW91573 EAW91574 P28324 AF075044 AI002107 AI005122 AK024944 AL117645 BC040145 AAH40145 BC063676 AAH63676 BE041598 BE675475 BE676052 BF433322 BX346360 EU446469 ABZ91998 M85164 AAA03632 M85165 AAA03631 T27937 XM_005244950 XP_005245007 XM_005244951 XP_005245008 XR_426764 XR_426766 XR_921752 XR_921753 NM_001973 NP_001964 NM_021795 NP_068567
|
| Function |
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
MAPK signaling pathway, HTLV-I infection, Transcriptional misregulation in cancer
|