ELK4

Gene Symbol	ELK4
Entrez Gene	2005
Alt Symbol	SAP1
Species	Human
Gene Type	protein-coding
Description	ELK4, ETS-domain protein (SRF accessory protein 1)
Other Description	ETS domain-containing protein Elk-4|SAP-1|serum response factor accessory protein 1
Swissprots	P28324 P28323 Q6GSJ2
Accessions	CCV01469 CCV01470 EAW91570 EAW91571 EAW91572 EAW91573 EAW91574 P28324 AF075044 AI002107 AI005122 AK024944 AL117645 BC040145 AAH40145 BC063676 AAH63676 BE041598 BE675475 BE676052 BF433322 BX346360 EU446469 ABZ91998 M85164 AAA03632 M85165 AAA03631 T27937 XM_005244950 XP_005245007 XM_005244951 XP_005245008 XR_426764 XR_426766 XR_921752 XR_921753 NM_001973 NP_001964 NM_021795 NP_068567
Function	Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. {ECO:0000269|PubMed:22722849}.
Subcellular Location	Nucleus.
Top Pathways	MAPK signaling pathway, HTLV-I infection, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ELK4 293T Cell Transient Overexpression Lysate(Denatured) - H00002005-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ELK4 293 Cell Lysate - 409182 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

ELK4 293 Cell Lysate - 405930 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ELK4 Overexpression Lysate (Denatured) - H00002005-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

ELK4 Overexpression Lysate (Native) - NBL1-10235 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

ELK4 Overexpression Lysate (Native) - NBL1-10234 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ELK4 Over-expression Lysate Product - GWB-D94579 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ELK4 Over-expression Lysate Product - GWB-BE003B from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

ELK4 Overexpression Lysate (Denatured) - H00002005-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human ELK4 Knockdown Stable Cell Line - CSC-DC004862 from Creative biogene Category Cell Line Species Human

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