LIN28B

Gene Symbol	LIN28B
Entrez Gene	389421
Alt Symbol	CSDD2
Species	Human
Gene Type	protein-coding
Description	lin-28 homolog B (C. elegans)
Other Description	Lin-28.2|lin-28B|protein lin-28 homolog B
Swissprots	B2RPN6 A1L165 Q6ZN17 Q5TCM4
Accessions	CDI44686 EAW48433 EAW48434 Q6ZN17 AK131411 BAD18558 AW674597 BC127712 AAI27713 BC127713 AAI27714 BC137526 AAI37527 BC137527 AAI37528 BC141959 BC141960 AAI41961 BC150537 AAI50538 BC150538 AAI50539 DQ127228 AAZ38897 XM_006715477 XP_006715540 XM_011535818 XP_011534120 NM_001004317 NP_001004317
Function	Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. {ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396}.
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly cytoplasmic at G1 phase, accumulates in the nucleus in S and G2 phases. The frequency of nuclear localization in S and in G2 phases is 60% and 30%, respectively.
Tissue Specificity	High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level). {ECO:0000269|PubMed:16971064}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

LIN28B (D4H1) Rabbit mAb - 11965 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D4H1

LIN28B Antibody - 4196 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

LIN28B Antibody (Mouse Preferred) - 5422 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

LIN-28B (F-21) - sc-130802 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

LIN-28B (H-91) - sc-367926 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-Lin28B antibody - ab71415 from Abcam Prices $384.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Lin28B antibody - ab115698 from Abcam Prices $384.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Lin28B antibody - ab119367 from Abcam Prices $378.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (C-Terminus) - LS-C183948 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa6-36, AP) - LS-C237137 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa6-36, Biotin) - LS-C237139 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa6-36, APC) - LS-C237138 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa6-36, Azide-free, HRP) - LS-C248710 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa6-36, PE) - LS-C237140 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa1-50) - LS-C290253 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa6-36, FITC) - LS-C250004 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa200-250) - LS-C290254 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa6-36) - LS-C322667 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa242-246) - LS-C205192 from LifeSpan Bioscience Prices $265.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (C-Terminus) - LS-C345484 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa218-250) - LS-C98241 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-LIN28B Antibody (aa1-30) IHC-plus™ - LS-B3423 from LifeSpan Bioscience Prices $395.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

LIN-28B Antibody - AF7726 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

LIN-28B Antibody - NBP2-32352 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LIN-28B Antibody - NBP1-50529 from Novus Biologicals Prices $329.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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