| Gene Symbol |
LIN28B
|
| Entrez Gene |
389421
|
| Alt Symbol |
CSDD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lin-28 homolog B (C. elegans)
|
| Other Description |
Lin-28.2|lin-28B|protein lin-28 homolog B
|
| Swissprots |
B2RPN6 A1L165 Q6ZN17 Q5TCM4
|
| Accessions |
CDI44686 EAW48433 EAW48434 Q6ZN17 AK131411 BAD18558 AW674597 BC127712 AAI27713 BC127713 AAI27714 BC137526 AAI37527 BC137527 AAI37528 BC141959 BC141960 AAI41961 BC150537 AAI50538 BC150538 AAI50539 DQ127228 AAZ38897 XM_006715477 XP_006715540 XM_011535818 XP_011534120 NM_001004317 NP_001004317
|
| Function |
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. {ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic at G1 phase, accumulates in the nucleus in S and G2 phases. The frequency of nuclear localization in S and in G2 phases is 60% and 30%, respectively.
|
| Tissue Specificity |
High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level). {ECO:0000269|PubMed:16971064}.
|