LIN28B

Gene Symbol	LIN28B
Entrez Gene	389421
Alt Symbol	CSDD2
Species	Human
Gene Type	protein-coding
Description	lin-28 homolog B (C. elegans)
Other Description	Lin-28.2|lin-28B|protein lin-28 homolog B
Swissprots	B2RPN6 A1L165 Q6ZN17 Q5TCM4
Accessions	CDI44686 EAW48433 EAW48434 Q6ZN17 AK131411 BAD18558 AW674597 BC127712 AAI27713 BC127713 AAI27714 BC137526 AAI37527 BC137527 AAI37528 BC141959 BC141960 AAI41961 BC150537 AAI50538 BC150538 AAI50539 DQ127228 AAZ38897 XM_006715477 XP_006715540 XM_011535818 XP_011534120 NM_001004317 NP_001004317
Function	Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. {ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396}.
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly cytoplasmic at G1 phase, accumulates in the nucleus in S and G2 phases. The frequency of nuclear localization in S and in G2 phases is 60% and 30%, respectively.
Tissue Specificity	High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level). {ECO:0000269|PubMed:16971064}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human Lin28B full length protein - ab134596 from Abcam Category Protein Source E. coli Species Human

LIN28B Antibody Blocking Peptide - LS-E3658 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LIN28B Antibody Blocking Peptide - LS-E3657 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LIN28B Blocking Peptide - LS-E3659 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LIN-28B Protein - NBP2-23196 from Novus Biologicals Category Protein Prices $269.00 Sizes 10 µg Source E.coli Species Human

LIN-28B Peptide - P0477 from Novus Biologicals Category Peptide Species Human

LIN-28B Peptide - P0476 from Novus Biologicals Category Peptide Species Human

LIN-28B Peptide - P0475 from Novus Biologicals Category Peptide Species Human

LIN28B-Antibody-Center-Blocking-Peptide - BP1485c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LIN28B-Antibody-C-term-Blocking-Peptide - BP1485b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LIN28B-Antibody-N-term-Blocking-Peptide - BP1485a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Lin28B protein (His tag) - 80R-2506 from Fitzgerald Category Protein Prices $270.00 Sizes 10 µg Source E.coli

LIN28B (1-250, His-tag) - AR50578PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

LIN28B (1-250, His-tag) - AR50578PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

LIN28B - P5872 from Acris Antibodies Category Protein Prices $500.00 Sizes 10 µg Species Human

Lin28B, 1-250aa, Human, His tag, E.coli - 01-P1754 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

LIN28B fusion protein - ag21241 from Proteintech Group Category Protein Species Human

LIN28B Human - PRPS-1256 from NeoScientific Category Protein Prices $65.00, $169.00, $1,560.00 Sizes 1 µg, 5 µg, 50 µg Source E.coli. Species Human

Recombinant Human Lin-28 Homolog B (C. elegans), His-tagged - LIN28B-7186H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human LIN28B - LIN28B-1034H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Protein lin-28 homolog B(LIN28B) - CSB-YP741049HU CSB-EP741049HU CSB-BP741049HU CSB-MP741049HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Lin28B, 1-250aa, Human, His tag, E.coli - ATGP1754 from ATGen Category Protein Prices $240.00, $720.00 Sizes 10 µg, 50 µg Species Human

LIN28B Protein (Recombinant) - abx263313 from Abbexa Category Protein

LIN28B (full length, N-term HIS tag) - TP760648 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

LIN-28B Recombinant Protein Antigen - NBP2-32352PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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