FOXP3

Gene Symbol FOXP3
Entrez Gene 50943
Alt Symbol AIID, DIETER, IPEX, JM2, PIDX, XPID
Species Human
Gene Type protein-coding
Description forkhead box P3
Other Description FOXP3delta7|forkhead box protein P3|immune dysregulation, polyendocrinopathy, enteropathy, X-linked|immunodeficiency, polyendocrinopathy, enteropathy, X-linked|scurfin
Swissprots Q14DD8 O60827 Q9BZS1 Q4ZH51 B9UN80 B7ZLG0 A5HJT1
Accessions CAY55968 CCF77062 CDH61704 EAW50671 EAW50672 EAW50673 Q9BZS1 AF277993 AAG53607 AJ005891 CAA06748 AK292052 BAF84741 AK299988 BAG61809 BC111853 AAI11854 BC113401 AAI13402 BC113403 AAI13404 BC143785 AAI43786 BC143786 AAI43787 BQ184335 DB342786 DQ010327 AAY27088 EF534714 ABQ15210 EU855812 ACJ46653 HQ258232 ADR82986 XM_006724533 XP_006724596 XM_011543915 XP_011542217 XM_011543916 XP_011542218 XM_011543917 XP_011542219 XM_011543918 XP_011542220 XM_011543919 XP_011542221 NM_001114377 NP_001107849 NM_014009 NP_054728
Function Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon- gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone ace
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:22678915, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:23973223}. Cytoplasm {ECO:0000269|PubMed:22678915}. Note=Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). {ECO:0000250|UniProtKB:Q99JB6, ECO:0000269|PubMed:22678915}.
Top Pathways Inflammatory bowel disease (IBD)

FOXP3 CRISPR/Cas9 KO Plasmid (h) - sc-400542 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FOXP3 HDR Plasmid (h) - sc-400542-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FOXP3 Double Nickase Plasmid (h) - sc-400542-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FOXP3 Double Nickase Plasmid (h2) - sc-400542-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FOXP3 CRISPR Activation Plasmid (h) - sc-400542-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FOXP3 CRISPR Activation Plasmid (h2) - sc-400542-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FOXP3 Lentiviral Activation Particles (h) - sc-400542-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FOXP3 Lentiviral Activation Particles (h2) - sc-400542-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FOXP3 siRNA (h) - sc-43569 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FOXP3 shRNA Plasmid (h) - sc-43569-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FOXP3 shRNA (h) Lentiviral Particles - sc-43569-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FoxP3 RNAi - H00050943-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU130241 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8915 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8915 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FOXP3 siRNA (Human) - CRH9437 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FOXP3 - MBS8227679 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FOXP3 siRNA (r) - sc-270590 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Rat

FOXP3 shRNA Plasmid (r) - sc-270590-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Rat

FOXP3 shRNA (r) Lentiviral Particles - sc-270590-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Rat

shRNA set against Human FOXP3 (NM_014009.3) - SHH296825 from Creative biogene

Category siRNA
Species Reactivities Human

FOXP3 shRNA Plasmid (Human) - CHH9437 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FOXP3 miRNA 3'UTR clone - MiUTR1H-03834 from Creative biogene

Species Reactivities Human
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