| Gene Symbol |
INSIG2
|
| Entrez Gene |
51141
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
insulin induced gene 2
|
| Other Description |
INSIG-2|INSIG2 membrane protein|insulin induced protein 2|insulin-induced gene 2 protein
|
| Swissprots |
Q9Y5U4 Q8TBI8 A8K5W8
|
| Accessions |
AAX93280 EAW95199 EAW95200 Q9Y5U4 AF125392 AAD43048 AF527632 AAN28333 AK021692 AK291433 BAF84122 AK298599 BAG60785 AL080184 BC022475 AAH22475 BX647805 XM_005263690 XP_005263747 XM_011511292 XP_011509594 NM_016133 NP_057217
|
| Function |
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:16606821}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12242332}; Multi-pass membrane protein {ECO:0000269|PubMed:12242332}.
|
![Western Blot: INSIG-2 Overexpression Lysate (Adult Normal) [NBL1-12004] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for INSIG-2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3481_INSIG-2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12004-img0002.jpg)