INSIG2

Gene Symbol	INSIG2
Entrez Gene	51141
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	insulin induced gene 2
Other Description	INSIG-2|INSIG2 membrane protein|insulin induced protein 2|insulin-induced gene 2 protein
Swissprots	Q9Y5U4 Q8TBI8 A8K5W8
Accessions	AAX93280 EAW95199 EAW95200 Q9Y5U4 AF125392 AAD43048 AF527632 AAN28333 AK021692 AK291433 BAF84122 AK298599 BAG60785 AL080184 BC022475 AAH22475 BX647805 XM_005263690 XP_005263747 XM_011511292 XP_011509594 NM_016133 NP_057217
Function	Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:16606821}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:12242332}; Multi-pass membrane protein {ECO:0000269|PubMed:12242332}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Insig2 full length protein - ab162432 from Abcam Category Protein Source Wheat germ Species Human

INSIG2 Antibody Blocking Peptide - LS-E14605 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human INSIG-2 Protein - H00051141-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

INSIG2 Blocking Peptide - 33R-5639 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

INSIG2 - H00051141-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

INSIG2 - H00051141-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

INSIG2 fusion protein - ag14279 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

INSIG2 fusion protein - ag14072 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

INSIG2 - TP305274 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

INSIG2 Peptide, Human - M34GP07673H from Creative Peptides Category Peptide Source Synthetic. Species Human

Insulin-induced gene 2 protein (INSIG2), Recombinant Protein - MBS7017502 from MyBioSource Category Protein Prices $1,040.00, $2,030.00, $3,235.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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