INSIG2

Gene Symbol INSIG2
Entrez Gene 51141
Alt Symbol -
Species Human
Gene Type protein-coding
Description insulin induced gene 2
Other Description INSIG-2|INSIG2 membrane protein|insulin induced protein 2|insulin-induced gene 2 protein
Swissprots Q9Y5U4 Q8TBI8 A8K5W8
Accessions AAX93280 EAW95199 EAW95200 Q9Y5U4 AF125392 AAD43048 AF527632 AAN28333 AK021692 AK291433 BAF84122 AK298599 BAG60785 AL080184 BC022475 AAH22475 BX647805 XM_005263690 XP_005263747 XM_011511292 XP_011509594 NM_016133 NP_057217
Function Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. {ECO:0000269|PubMed:12242332, ECO:0000269|PubMed:16606821}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12242332}; Multi-pass membrane protein {ECO:0000269|PubMed:12242332}.

INSIG-2 CRISPR/Cas9 KO Plasmid (h) - sc-402255 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-2 HDR Plasmid (h) - sc-402255-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-2 Double Nickase Plasmid (h) - sc-402255-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-2 Double Nickase Plasmid (h2) - sc-402255-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-2 CRISPR Activation Plasmid (h) - sc-402255-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-2 CRISPR Activation Plasmid (h2) - sc-402255-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-2 Lentiviral Activation Particles (h) - sc-402255-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-2 Lentiviral Activation Particles (h2) - sc-402255-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INSIG-2 siRNA (h) - sc-45781 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INSIG-2 shRNA Plasmid (h) - sc-45781-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INSIG-2 shRNA (h) Lentiviral Particles - sc-45781-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU063601 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10700 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10700 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09922 from Sigma-Aldrich

Category miRNA

INSIG2 siRNA (Human) - CRH9557 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

INSIG2 - MBS827444 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human INSIG2 (NM_016133.2) - SHH319833 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human INSIG2(NM_016133.2) - SHL178950 from Creative biogene

Category siRNA
Species Reactivities Human

Human INSIG2 siRNA - orb270059 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

INSIG2 shRNA Plasmid (Human) - CHH9557 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

INSIG2 miRNA 3'UTR clone - MiUTR1H-04961 from Creative biogene

Species Reactivities Human
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