| Gene Symbol | HLA-DQB1 |
|---|---|
| Entrez Gene | 3119 |
| Alt Symbol | CELIAC1, HLA-DQB, IDDM1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | major histocompatibility complex, class II, DQ beta 1 |
| Other Description | HLA class II histocompatibility antigen, DQ beta 1 chain|MHC DQ beta|MHC class II DQ beta chain|MHC class II HLA-DQ beta glycoprotein|MHC class II antigen DQB1|MHC class II antigen HLA-DQ-beta-1|MHC class2 antigen|lymphocyte antigen |
| Swissprots | Q8MH58 C8ZLJ8 A9YQA0 B1A0K6 Q9MYH2 C8ZL52 Q8SP70 P03992 O78221 B3VLT3 Q30081 Q30089 Q1M312 Q08GC8 Q30082 P79544 Q45UE3 O62861 Q5ISH3 Q2P9N3 P79526 Q30084 Q5W1E1 O78046 P01920 B5BLN7 Q8SND1 C9DRQ3 O98201 Q30076 Q643R4 C0MQ35 Q9BD17 B0S7Y7 Q30083 C0MQ34 P05537 Q29877 Q7YP69 Q29915 Q5ISH1 Q30095 A4USG5 Q6B9X1 Q30075 Q9TPA9 Q53I44 Q0E4V9 O78223 Q9XRY7 A2RPH3 Q29731 O19724 P79551 Q8SNB4 Q5G841 P79482 Q29966 Q564J6 O98034 Q38I47 Q2QK85 Q70VH8 Q9XRY6 A6N8I7 P01917 O19708 A4Q9R4 Q5Y7G8 B7VU69 Q31633 Q30080 C8ZLJ9 P01919 A1KR27 B1GXI3 Q4QZB5 Q8HWH0 Q29884 Q30061 Q8WMA3 A4USG2 Q9XRZ2 P01918 O19713 Q09035 |
| Accessions | AAA03249 AAA36237 AAA36238 AAA36239 AAA36240 AAA36241 AAA36242 AAA36243 AAA36245 AAA36246 AAA36247 AAA36271 AAA59577 AAA59709 AAA59710 AAA59711 AAA59712 AAA59775 AAA59776 AAA59778 AAA75521 AAA77049 AAA93181 AAA98746 AAB02681 AAB02682 AAB19215 AAB25221 AAB60325 AAB91991 AAC64403 AAC64605 AAD00003 AAD00006 AAD00007 AAD00008 AAD15002 AAD23990 AAD23991 AAD39697 AAD54423 AAD56412 AAF63192 AAK01944 AAK17120 AAK17121 AAK17122 AAK17123 AAK96012 AAK96013 AAL35222 AAL66389 AAL77085 AAM09472 AAM14401 AAM28883 AAM53072 AAM94360 AAP78473 AAP94731 AAQ88016 AAQ88017 AAQ88018 AAQ88019 AAQ88020 AAQ88021 AAQ88022 AAQ88023 AAQ88024 AAQ88025 AAQ88026 AAQ88027 AAQ88028 AAQ88029 AAQ88030 AAQ88031 AAQ88032 AAQ88033 AAQ88034 AAQ88035 AAQ88036 AAQ88037 AAQ88038 AAQ88039 AAQ88040 AAQ88041 AAQ88042 AAQ88043 AAQ88044 AAQ88045 AAQ88046 AAQ88047 AAT39543 AAT77952 AAU33811 AAU87973 AAU87977 AAU87980 AAU87982 AAU87986 AAU87988 AAU87991 AAU87994 AAU88002 AAU88006 AAU88009 AAU88012 AAU88015 AAU88017 AAU88020 AAU88024 AAU88027 AAU88030 AAU88032 AAU88036 AAV97949 AAX22127 AAX22128 AAX22129 AAX22130 AAX22131 AAX22132 AAX22133 AAX22134 AAX22135 AAX22136 AAX22137 AAX22138 AAY33730 AAY33731 AAY33732 AAY33733 AAY33734 AAY89656 AAZ20753 ABA06597 ABB05231 ABF50985 ABF56580 ABF56581 ABO87661 ABO87664 ABR24117 ABY26529 ABY26530 ABY26531 ACA28737 ACF16333 ACV66342 ADC29455 ADD23527 ADN88900 ADO17335 ADT80796 ADU03770 ADV78579 ADX97422 ADX97423 ADX97424 ADX97425 ADX99572 ADZ24220 ADZ38973 ADZ38974 ADZ38975 ADZ38977 ADZ38978 AEB65785 AEB65798 AEB91578 AEI58953 AEI87647 AEK95214 AEL87269 AEO14635 AEO14636 AEO14640 AEQ38591 AER40956 AER92543 AET21256 AET79254 AFD62904 AFD97749 AFK24447 AFM31009 AFM68913 AFN52226 AFO70101 AFP19430 AFQ55491 AFS51276 AFS51277 AFS51278 AFV74667 AFV74668 AFX62403 AFX62404 AFX62407 AFX62408 AFX62409 AFZ94564 AFZ94565 AFZ94566 AFZ94567 AFZ94568 AFZ94569 AFZ94601 AFZ94602 AFZ94603 AFZ94604 AFZ94605 AFZ94606 AFZ94607 AFZ94609 AFZ94610 AFZ94629 AFZ94630 AFZ94631 AFZ94632 AFZ94633 AFZ94634 AFZ94635 AFZ94636 AFZ94637 AFZ94639 AFZ94640 AFZ94641 AFZ94643 AFZ94644 AFZ94646 AFZ94647 AFZ94648 AFZ94650 AFZ94651 AFZ94652 AFZ94653 AFZ94654 AFZ94655 AFZ94657 AFZ94658 AFZ94659 AFZ94660 AFZ94661 AFZ94662 AFZ94663 AFZ94665 AFZ94666 AFZ94667 AFZ94668 AFZ94669 AFZ94670 AFZ94671 AFZ94673 AFZ94674 AFZ94675 AFZ94676 AFZ94677 AFZ94678 AFZ94679 AFZ94682 AFZ94683 AFZ94684 AFZ94685 AFZ94686 AFZ94687 AFZ94688 AFZ94689 AFZ94693 AFZ94694 AGD99115 AGE13907 AGE13908 AGE13909 AGE13910 AGE13911 AGE13912 AGE13913 AGE13914 AGE13915 AGE13916 AGE13917 AGE13920 AGE13921 AGG68854 AGG68857 AGG79751 AGG79753 AGG79754 AGG79755 AGG79756 AGG79757 AGG79758 AGG79759 AGG79760 AGG79761 AGG79762 AGG79763 AGG79797 AGG79818 AGG79819 AGG79820 AGG79821 AGG79822 AGG79823 AGG79824 AGG79825 AGG79826 AGG79827 AGG79829 AGG79830 AGG79832 AGG79833 AGG79836 AGG79838 AGG79839 AGG79840 AGG79842 AGG79844 AGG79845 AGG79852 AGG79853 AGG79855 AGG79856 AGG79859 AGG79860 AGG79861 AGG79862 AGG79863 AGG79864 AGG79865 AGG79867 AGG79868 AGG79869 AGG79870 AGG79871 AGG79883 AGG79884 AGG79915 AGG79916 AGG79917 AGG79918 AGG79919 AGG79947 AGG79948 AGG79949 AGG79951 AGG79977 AGG79978 AGG79979 AGG79980 AGG79981 AGG79982 AGG79983 AGG79984 AGG80002 AGG80003 AGG80004 AGG80005 AGG80006 AGG80030 AGG80031 AGG80032 AGG80033 AGG80035 AGG80036 AGG91352 AGI37641 AGI37642 AGI48714 AGI48715 AGI48716 AGI48717 AGI48718 AGI48719 AGI48720 AGI78870 AGJ84098 AGJ84099 AGJ84101 AGJ84102 AGJ84103 AGJ84104 AGJ84105 AGK07576 AGK07577 AGK07578 AGK44333 AGK44334 AGK44335 AGK44337 AGK44338 AGK44352 AGL09224 AGL09225 AGL09226 AGL09227 AGL09228 AGL09229 AGL09231 AGL73149 AGL73150 AGL73151 AGL73152 AGL73153 AGL73154 AGL73155 AGL73156 AGL73157 AGL73158 AGL73159 AGL73160 AGL73161 AGL73162 AGL73163 AGL73164 AGO63368 AGO86847 AGO97382 AGQ53943 AGT79681 AGT79682 AGT79683 AGT79684 AGT79685 AGT79686 AGV40759 AGV40760 AGW82916 AGW82917 AGW82918 AGW82920 AGW82921 AGW82922 AGW82923 AGW82924 AGW82925 AGW82926 AGW82927 AGW82928 AGW82929 AGW82930 AGW82931 AGW82932 AGW82933 AGW82934 AGW82935 AGW82936 AGW82947 AGW82948 AGW82949 AGW82950 AGW82951 AGW82952 AGW82953 AGW82954 AGW82955 AGW82956 AGW82957 AGZ13681 AHA80965 AHA80966 AHB20189 AHF52836 AHW47922 AHW47939 AHW47956 AHW47973 AHY62278 AHY62279 AHY62280 AHY62281 AHY62282 AHY62283 AHY62284 AHY62285 AHY62286 AHY62287 AHY62288 AHY62290 AHY62291 AHY62292 AHY62293 AHY62294 AHY62296 AHY62297 AHY62298 AHY62299 AHY62302 AHY62303 AHY62304 AHY62306 AHY62308 AHY62309 AHY62310 AHY62311 AHY62314 AHY62315 AHY62316 AHY62319 AHY62320 AHY62321 AHY62322 AHY62323 AHY62324 AHY62325 AHY62326 AHY62329 AHY62330 AHY62331 AHY62332 AHY62333 AHY62334 AHY62335 AHY62336 AHY62337 AHY62338 AHY62342 AHY62343 AHY62344 AHY62345 AHY62346 AHY62348 AHY62350 AHY62352 AHY62353 AHY62355 AHY62356 AHY62358 AHY62359 AHY62360 AHY62361 AHY62362 AHY62363 AHY62365 AHY62366 AHY62367 AHY62368 AHY62369 AHY62370 AHY62371 AHY62372 AHY62373 AHY62374 AHY62375 AHY62376 AHY62378 AHY62380 AHY62381 AHY62382 AHY62383 AHY62384 AHY62385 AHY62386 AHY62387 AHY62388 AHY62389 AHY62393 AHY62394 AHY62395 AHY62396 AHY62397 AHY62398 AHY62399 AHY62400 AHY62402 AHY62403 AHY62404 AHY62405 AHY62406 AHY62408 AHY62409 AHY62411 AHY62414 AHY62417 AHY62418 AHY62419 AHY62420 AHY62421 AHY62423 AHY62425 AHY62426 AHY62427 AHY62428 AHY62429 AHY62430 AHY62432 AHY62434 AHY62435 AHY62437 AHY62438 AHY62439 AHY62440 AHY62441 AHY62442 AHY62443 AHY62447 AHY62450 AHY62451 AHY62452 AHY62454 AHY62455 AHY62459 AHY62460 AHY62461 AHY62462 AHY62463 AHY62464 AHY62467 AHY62468 AHY62469 AHY62471 AHY62472 AHY62473 AHY62475 AHY62476 AHY62477 AHY62478 AHY62479 AHY62480 AHY62481 AHY62482 AHY62483 AHY62485 AHY62486 AHY62487 AHY62488 AHY62491 AHY62493 AHY62494 AHY62497 AHY62498 AHY62501 AHY62502 AHY62503 AHY62504 AHY62505 AHY62507 AHY62508 AHY62509 AHY62510 AHY62512 AHY62513 AHY62514 AHY62515 AHY62516 AHY62517 AHY62518 AHY62519 AHY62521 AHY62523 AHY62524 AHY62525 AHY62526 AHY62527 AHY62529 AHY62530 AHY62535 AHY62537 AHY62538 AHY62539 AHY62540 AHY62542 AHY62543 AHY62544 AHY62545 AHY62546 AHY62547 AHY62548 AHY62550 AHY62552 AHY62553 AHY62554 AHY62555 AHY82109 AHY82110 AHY82113 AHY82114 AHY82116 AHY82120 AHY82121 AHY82122 AHY82123 AHY82124 AHY82125 AHY82126 AHY82127 AHY82129 AHY82130 AHY82136 AHY82137 AHY82138 AHY82139 AHY82140 AHY82143 AHY82144 AHY82145 AHY82146 AHY82150 AHY82151 AHY82152 AHY82153 AHY82154 AHY82156 AHY82159 AHY82161 AHY82162 AHY82164 AHY82165 AHY82166 AHY82168 AHY82169 AHY82171 AHY82172 AHY82173 AHY82174 AHY82175 AHY82176 AHY82177 AHY82178 AHY82181 AHY82182 AHY82183 AHY82184 AHY82186 AHY82187 AHY82188 AHY82189 AHY82190 AHY82191 AHY82192 AHY82193 AHY82194 AHY82195 AHY82197 AHY82198 AHY82199 AHY82200 AHY82203 AHY82205 AHY82206 AHY82207 AHY82208 AHY82209 AHY82210 AHY82211 AHY82213 AHY82214 AHY82217 AHY82219 AHY82220 AHY82221 AHY82222 AHY82223 AHY82224 AHY82225 AHY82227 AHY82228 AHY82229 AHY82233 AHY82234 AHY82236 AHY82237 AHY82238 AHY82243 AHY82244 AHY82245 AHY82246 AHY82248 AHY82251 AHY82253 AHY82254 AHY82258 AHY82259 AHY82260 AHY82261 AHY82262 AHY82263 AHY82264 AHY82265 AHY82267 AHY82268 AHY82269 AHY82270 AHY82272 AHY82273 AHY82274 AHY82275 AHY82277 AHY82278 AHY82280 AHY82282 AHY82283 AHY82284 AHY82287 AHY82289 AHY82290 AHY82291 AHY82292 AHY82293 AHY82294 AHY82295 AHY82297 AHY82298 AHY82299 AHY82305 AHY82306 AHY82307 AHY82308 AHY82309 AHY82310 AHY82311 AHY82312 AHY82314 AHY82315 AHY82316 AHY82317 AHY82318 AHY82319 AHY82320 AHY82322 AHY82325 AHY82326 AHY82328 AHY82329 AHY82330 AHY82331 AHY82332 AHY82333 AHY82334 AHY82335 AHY82336 AHY82337 AHY82338 AHY82339 AHY82340 AHY82342 AHY82343 AHY82344 AHY82345 AHY82346 AHY82348 AHY82349 AHY82350 AHY82352 AHZ31030 AHZ31031 AHZ31032 AHZ31034 AHZ31035 AHZ31040 AHZ31041 AHZ31043 AHZ31045 AHZ31047 AHZ31048 AHZ31051 AHZ31052 AHZ31053 AHZ31054 AHZ31055 AHZ31056 AHZ31057 AHZ31058 AHZ31060 AHZ31062 AHZ31064 AHZ31066 AHZ31068 AHZ31069 AHZ31072 AHZ31073 AHZ31075 AHZ31076 AHZ31077 AHZ31079 AHZ31083 AHZ31084 AHZ31085 AHZ31086 AHZ31089 AHZ31091 AHZ31093 AHZ31094 AHZ31095 AHZ31096 AHZ31097 AHZ31099 AHZ31100 AHZ31101 AHZ31103 AHZ31104 AHZ31105 AHZ31106 AHZ31108 AHZ31109 AHZ31110 AHZ31111 AHZ31113 AHZ31114 AHZ31116 AHZ31118 AHZ31119 AHZ31120 AHZ31122 AHZ31123 AHZ31126 AHZ31127 AHZ31132 AHZ31133 AHZ31134 AHZ31140 AHZ31141 AHZ31142 AHZ31144 AHZ31146 AHZ31147 AHZ31149 AHZ31150 AHZ31151 AHZ31152 AHZ31153 AHZ31156 AIA09921 AIA09922 AIA22373 AIJ03130 AIJ28809 AIL30473 AIY25918 AIY25920 AIZ66892 AIZ66893 AJA90830 AJA90831 AKA20568 AKE47357 BAA06217 BAA11413 BAA19528 BAD95610 BAM28991 BAM28992 BAM64859 BAM64860 BAM64861 BAM64864 BAN59788 BAN59794 BAN59800 BAN59806 BAN59812 BAN59824 BAN59830 BAN59842 CAA04630 CAA04631 CAA09928 CAA09929 CAA09990 CAA11215 CAA71450 CAA84482 CAC19575 CAC27418 CAD47822 CAD59445 CAD89801 CAD97476 CAH69441 CAI79639 CAJ57391 CAJ76977 CAJ76978 CAJ90955 CAJ90956 CAK50560 CAL15002 CAL25326 CAL45572 CAL47037 CAL48285 CAL64838 CAM07104 CAM20182 CAM32717 CAM88661 CAP12879 CAP12880 CAQ16179 CAW24712 CAX33836 CAX62164 CAX62165 CAX83213 CAZ65676 CBE66554 CBF35736 CBF35739 CBV36793 CBW39470 CBW39471 CBW39472 CBW39473 CBW39475 CBW39477 CBW39478 CBY85628 CBY89198 CBY94014 CBZ13170 CCA30656 CCA61802 CCB96441 CCB96442 CCB96444 CCB96445 CCB96446 CCB96447 CCB96448 CCB96449 CCB96450 CCB96452 CCB96453 CCB96454 CCB96456 CCB96457 CCB96458 CCB96459 CCB96460 CCB96461 CCB96462 CCB96463 CCB96464 CCB96465 CCB96466 CCB96467 CCB96468 CCB96469 CCB96470 CCB96471 CCB96472 CCB96487 CCB96501 CCB96504 CCB96505 CCB96513 CCB96516 CCB96517 CCB96518 CCB96519 CCB96520 CCB96521 CCB96522 CCB96523 CCB96524 CCB96525 CCB96526 CCB96528 CCF23013 CCG47944 CCH14858 CCH14860 CCH35807 CCH35808 CCH35809 CCH35811 CCH35812 CCH35813 CCH35814 CCH35815 CCH35816 CCH35817 CCH35818 CCH35819 CCH35820 CCH35821 CCH35822 CCH35823 CCH35824 CCH35825 CCH35826 CCH35827 CCH35828 CCH35829 CCH35830 CCH35831 CCH35832 CCH35833 CCH35858 CCH35859 CCH35860 CCH35861 CCH35873 CCH35874 CCH35875 CCH35876 CCH35877 CCH35878 CCH35879 CCH35880 CCH35881 CCH35882 CCH35883 CCH35884 CCH35885 CCH57450 CCH57451 CCH57452 CCH57454 CCH57455 CCH57456 CCH57457 CCH57458 CCH57459 CCH57460 CCH57461 CCH57462 CCH57463 CCH57464 CCH57465 CCH57466 CCH57467 CCH57468 CCH57469 CCH57470 CCH57471 CCH57472 CCH57473 CCH57474 CCH57475 CCH57476 CCH57501 CCH57502 CCH57503 CCH57504 CCH57516 CCH57517 CCH57518 CCH57519 CCH57520 CCH57521 CCH57522 CCH57523 CCH57524 CCH57525 CCH57526 CCH57527 CCH57528 CCM44489 CCN97892 CCQ92226 CCV01112 CCV01191 CCV01192 CCW28093 CDF66363 CDH92854 CDI27932 CDI27934 CDI27935 CDI27936 CDI27937 CDJ79848 CDL18810 CDL18971 CDL67652 CDL75426 CDM21837 CDN39813 CDN39818 CDN39819 CDQ51697 CEF48065 CEF48117 CEF48118 CEJ16374 CEJ25502 CEK40930 CEK40931 CEN62970 CQR91473 CQR91474 EAW50577 EAW50578 EAW50579 EAW50580 EAW50581 P01920 AB209580 BAD92817 AB209638 BAD92875 AF000447 AAB86436 AF113250 AAD17203 AF195245 AAF28315 AF291674 AAK91824 AK097297 AK295255 BAG58244 AK295476 BAG58403 AK295695 BAG58545 AK296613 BAG59223 AK304543 BAG65340 AK316333 BAH14704 AY656681 AAV71028 AY656682 AAV71029 AY656683 AAV71030 BC012106 AAH12106 BC128595 AAI28596 BF510934 BQ012862 DC409119 DQ136036 AAZ67362 DQ892298 ABM83224 DQ895497 ABM86423 J00198 AAA59788 L34095 AAC41963 L34096 AAC41964 L34097 AAC41965 L34098 AAC41966 L34099 AAC41967 L34100 AAC41968 L34101 AAC41969 L34102 AAC41970 L34103 AAC41971 L34104 AAC41972 L34105 AAC41973 L34106 AAC41974 L34107 AAC41975 L40179 AAC41976 L40180 AAA92331 L40181 AAA92332 L42626 AAA85335 M13279 AAA59807 M14189 AAA36268 M16276 AAA59823 M16996 AAA59770 M17204 AAA59698 M17206 AAA59696 M17207 AAA59697 M17563 AAA59764 M17564 AAA59765 M17565 AAA59766 M17955 AAA36269 M19239 AAA52319 M20432 AAA59769 M20505 AAA59773 M21135 AAA59767 M22549 AAA59820 M22550 AAA59821 M24364 AAA36236 M25024 AAA59792 M25025 AAA59793 M25325 AAA59675 M25326 AAA59676 M25327 AAA59677 M26042 AAA36270 M32577 AAA59768 M33907 AAA52672 M35730 AAA59763 M35982 AAA36251 M57649 AAA63217 M57650 AAA63216 M59800 AAA64235 M59801 AAA64234 M60028 AAA59755 M81140 AAA59771 M81141 AAA59772 S79787 AAD14316 U63321 AAB05807 U66400 AAB51698 U83582 AAB41231 U83585 AAC02814 V00529 CAA23788 X00369 X03068 CAA26872 X96420 CAA65280 NM_001243961 NP_001230890 NM_001243962 NP_001230891 NM_002123 NP_002114 |
| Function | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Top Pathways | Inflammatory bowel disease (IBD), HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection |