PAX6

Gene Symbol PAX6
Entrez Gene 5080
Alt Symbol AN, AN2, D11S812E, FVH1, MGDA, WAGR
Species Human
Gene Type protein-coding
Description paired box 6
Other Description aniridia type II protein|oculorhombin|paired box homeotic gene-6|paired box protein Pax-6
Swissprots Q99413 P26367 Q6N006
Accessions AAB30690 AAB30691 AAB30692 AAN86817 AAO27433 AAP57671 AAP74576 AAR10412 AAR10413 AAS44593 AAS44594 ABB55262 ABB55263 ADP65746 EAW68233 EAW68234 EAW68235 EAW68236 P26367 AB209177 BAD92414 AB593092 BAJ84032 AB593093 BAJ84033 AB593094 BAJ84034 AK074881 BAG52023 AK094172 AK094249 AK314470 AY047583 AAK95849 AY707088 AAU12168 BC011953 AAH11953 BE221553 BI789171 BI816814 BM313099 BM557761 BM725029 BP394398 BP394576 BU072567 BX089704 BX114225 BX440968 BX640762 CAE45868 CA397536 CD673930 CV569250 DA078958 DA079367 DA141443 DA183294 DQ891436 ABM82362 DQ894612 ABM85538 F07809 GQ141695 ACZ28705 KP255960 M77844 AAA59962 M93650 AAA36416 XM_005252954 XP_005253011 XM_005252955 XP_005253012 XM_005252956 XP_005253013 XM_005252958 XP_005253015 XM_006718246 XP_006718309 XM_011520146 XP_011518448 XM_011520147 XP_011518449 XM_011520148 XP_011518450 XM_011520149 XP_011518451 XM_011520150 XP_011518452 XM_011520151 XP_011518453 XM_011520152 XP_011518454 XM_011520153 XP_011518455 NM_000280 NP_000271 NM_001127612 NP_001121084 NM_001258462 NP_001245391 NM_001258463 NP_001245392 NM_001258464 NP_001245393 NM_001258465 NP_001245394 NM_001604 NP_001595
Function Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes. {ECO:0000250}.
Subcellular Location Nucleus.
Tissue Specificity Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
Top Pathways Maturity onset diabetes of the young, Signaling pathways regulating pluripotency of stem cells

Pax-2/6 (N-19) - sc-7751 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Pax-2/6 (N-19): sc-7751. Western blot analysis of Pax-2/6 expression in KNRK whole cell lysate.

Pax-6 (AD1.5) - sc-53106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pax-6 (AD1.5): sc-53106. Western blot analysis of Pax-6 expression in ARPE-19 whole cell lysate.

Pax-6 (AD2.35) - sc-53108 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pax-6 (AD2.35): sc-53108. Western blot analysis of Pax-6 expression in non-transfected: sc-110760 (A) and human Pax-6 transfected: sc-113085 (B) 293 whole cell lysates.

Pax-6 (AD2.38) - sc-32766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pax-6 (AD2.38): sc-32766. Western blot analysis of Pax-6 expression in non-transfected: sc-110760 (A) and human Pax-6 transfected: sc-113085 (B) 293 whole cell lysates.

Pax-6 (C-20) - sc-7750 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Pax-6 (C-20): sc-7750. Western blot analysis of Pax-6 expression in non-transfected: sc-117752 (A) and mouse Pax-6 transfected: sc-127299 (B) 293T whole cell lysates.

Pax-6 (H-295) - sc-11357 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Pax-6 (H-295): sc-11357. Western blot analysis of Pax-6 expression in Y79 nuclear extract (A) and rat eye tissue extract (B).

Anti-PAX6 antibody - ab85124 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fetal pancreas tissue labelling PAX6 with ab85124 at a dilution of 1/100.

Anti-PAX6 antibody - ab154253 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PAX6 antibody (ab154253) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-PAX6 antibody - ab89676 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-PAX6 antibody (ab89676) at 1 µg/ml + Human pancreas lysate at 50 µg

Anti-PAX6 antibody - ab103870 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PAX6 antibody (ab103870) at 1/100 dilution + Y79 cell line lysate at 35 µg

Anti-PAX6 antibody [1C8] - ab101437 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1C8
Anti-PAX6 antibody [1C8] (ab101437) + recombinant Human PAX6 protein

Anti-PAX6 antibody [EPR15858] - ab195045 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15858
Anti-PAX6 antibody [EPR15858] (ab195045) at 1/1000 dilution + Mouse eyeball lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-PAX6 antibody [EPR3352(2)] - ab109233 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3352(2)
Overlay histogram showing SHSY-5Y cells stained with ab109233 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab109233, 1/10000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SHSY-5Y cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-PAX6 antibody [PAX5I326] - ab51358 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PAX5I326
Anti-PAX6 antibody [PAX5I326] (ab51358)

Anti-PAX6 antibody [PR-1G2] - ab95333 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PR-1G2
All lanes : Anti-PAX6 antibody [PR-1G2] (ab95333) at 1 µg/mlLane 1 : PAX6 (aa 1-209) recombinant fragment at 0.2 µgLane 2 : Untransfected HEK-293 cell lysate at 20 µgLane 3 : HEK-293-PAX6 transfectant cell lysate at 20 µg

Anti-PAX6 antibody [PR-2D11] - ab95330 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PR-2D11
All lanes : Anti-PAX6 antibody [PR-2D11] (ab95330) at 1 µg/mlLane 1 : PAX6 (aa 1-209) recombinant fragment at 0.2 µgLane 2 : Untransfected HEK-293 cell lysate at 20 µgLane 3 : HEK-293-PAX6 transfectant cell lysate at 20 µg

Anti-PAX6 antibody - N-terminal - ab135080 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-PAX6 antibody - N-terminal (ab135080) at 1/500 dilution + Mouse brain total cell extract

Anti-PAX6 Antibody (clone 193CT15.2.2, AP) - LS-C250368 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 193CT15.2.2

Anti-PAX6 Antibody (clone 193CT15.2.2, APC) - LS-C250369 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 193CT15.2.2

Anti-PAX6 Antibody (clone 193CT15.2.2, Biotin) - LS-C250370 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 193CT15.2.2

Anti-PAX6 Antibody (clone 193CT15.2.2, FITC) - LS-C250371 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 193CT15.2.2

Anti-PAX6 Antibody (clone 193CT15.2.2, Azide-free, HRP) - LS-C250372 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 193CT15.2.2

Anti-PAX6 Antibody (clone 193CT15.2.2, PE) - LS-C250373 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 193CT15.2.2

Anti-PAX6 Antibody (APC) - LS-C265681 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAX6 Antibody (Biotin) - LS-C265682 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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