| Gene Symbol | GHR |
|---|---|
| Entrez Gene | 280805 |
| Alt Symbol | - |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | growth hormone receptor |
| Other Description | GH receptor|somatotropin receptor |
| Swissprots | Q9TUY7 Q9TQV9 Q5XM78 O46600 O77538 |
| Accessions | AAD45668 AAZ15272 AAZ15273 AAZ15274 AAZ15275 AAZ15276 AAZ15277 AAZ15280 AAZ15281 AAZ15282 AAZ15283 AAZ15284 AAZ15285 AAZ15286 AAZ15287 AAZ15288 AAZ15289 AAZ15290 AAZ15291 AAZ15292 AAZ15293 AAZ15294 AAZ15295 ABA70591 ABA70592 ABA70593 ABA70594 ABA70596 ABA70597 CAJ44122 DAA17887 O46600 AF036290 AAC33308 AF036291 AAC33309 AF036292 AAC33310 AF036293 AAC33311 AF036294 AAC33312 AF036295 AAC33313 AF036296 AAC33314 AF036297 AAC33315 AF044258 AAC02534 AF085281 AAD22521 AF326349 AAK97345 AY748827 AAU94310 X70041 CAA49635 NM_176608 NP_788781 |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. {ECO:0000250}. |
| Tissue Specificity | Highly expressed in both adult and fetal liver. Lower levels in kidney, anterior pituitary, skeletal muscle, adipose tissue and mammary gland. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, PI3K-Akt signaling pathway, Neuroactive ligand-receptor interaction |