| Gene Symbol |
CDKN1C
|
| Entrez Gene |
1028
|
| Alt Symbol |
BWCR, BWS, KIP2, WBS, p57, p57Kip2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
|
| Other Description |
cyclin-dependent kinase inhibitor 1C|cyclin-dependent kinase inhibitor p57
|
| Swissprots |
P49918
|
| Accessions |
AAB05896 BAA11014 BAA11015 EAX02524 EAX02525 P49918 BC039188 BC067842 AAH67842 BM673714 CD676249 EU570054 ACB69757 U22398 AAA85095 XM_005252732 XP_005252789 XM_006725126 XP_006725189 NM_000076 NP_000067 NM_001122630 NP_001116102 NM_001122631 NP_001116103
|
| Function |
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver. {ECO:0000269|PubMed:22634751}.
|
| Top Pathways |
Cell cycle
|