| Gene Symbol | COL4A1 |
|---|---|
| Entrez Gene | 1282 |
| Alt Symbol | BSVD |
| Species | Human |
| Gene Type | protein-coding |
| Description | collagen, type IV, alpha 1 |
| Other Description | COL4A1 NC1 domain|arresten|collagen IV, alpha-1 polypeptide|collagen alpha-1(IV) chain|collagen of basement membrane, alpha-1 chain |
| Swissprots | A7E2W4 P02462 Q9NYC5 B1AM70 Q86X41 Q1P9S9 Q8NF88 Q5VWF6 |
| Accessions | AAA53098 CAA31276 EAX09108 EAX09109 P02462 AA678474 AB209646 BAD92883 AF258349 AAF72630 AF363672 AAK53382 AF400431 AAK92480 AF536207 AAM97359 AY285780 AAP43112 BC047305 AAH47305 BC142626 AAI42627 BC151220 AAI51221 BU677787 CD613007 CN256264 DQ464183 ABE73157 EU260121 ABX47006 H40591 M10940 AAA52006 M10941 M11315 AAA52042 X03963 X05561 CAA29075 Y00706 CAA68698 XM_011521048 XP_011519350 NM_001303110 NP_001290039 NM_001845 NP_001836 |
| Function | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. |
| Tissue Specificity | Highly expressed in placenta. {ECO:0000269|PubMed:10811134, ECO:0000269|PubMed:16481288}. |
| Top Pathways | Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Protein digestion and absorption |