KYNU

Gene Symbol	KYNU
Entrez Gene	8942
Alt Symbol	KYNUU
Species	Human
Gene Type	protein-coding
Description	kynureninase
Other Description	L-kynurenine hydrolase
Swissprots	B2RCZ5 Q9BVW3 D3DP79 Q6I9T2 Q16719
Accessions	AAX93159 AAY14727 EAX11599 EAX11600 EAX11601 Q16719 AK223426 BAD97146 AK290900 BAF83589 AK292095 BAF84784 AK315343 BAG37742 AL548658 AW290980 AW296221 BC000879 AAH00879 CB151988 CR457423 CAG33704 HQ447861 ADQ32345 U57721 AAC50650 XM_011512101 XP_011510403 XM_011512102 XP_011510404 XM_011512103 XP_011510405 XM_011512104 XP_011510406 XM_011512105 XP_011510407 XR_923058 NM_001032998 NP_001028170 NM_001199241 NP_001186170 NM_003937 NP_003928
Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:8706755}.
Tissue Specificity	Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. {ECO:0000269|PubMed:8706755, ECO:0000269|PubMed:9180257}.
Top Pathways	Tryptophan metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

kynureninase CRISPR/Cas9 KO Plasmid (h) - sc-405705 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

kynureninase HDR Plasmid (h) - sc-405705-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kynureninase Double Nickase Plasmid (h) - sc-405705-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kynureninase Double Nickase Plasmid (h2) - sc-405705-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kynureninase CRISPR Activation Plasmid (h) - sc-405705-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

kynureninase CRISPR Activation Plasmid (h2) - sc-405705-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

kynureninase Lentiviral Activation Particles (h) - sc-405705-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kynureninase Lentiviral Activation Particles (h2) - sc-405705-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

kynureninase siRNA (h) - sc-95023 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

kynureninase shRNA Plasmid (h) - sc-95023-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

kynureninase shRNA (h) Lentiviral Particles - sc-95023-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Kynureninase RNAi - H00008942-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU002551 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11509 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11509 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01081 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01081

KYNU siRNA (Human) - CRH5915 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Kynureninase RNAi - H00008942-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human KYNU (NM_003937.2) - SHH327967 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human KYNU(NM_003937.2) - SHH140411 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human KYNU(NM_001032998.1) - SHH140447 from Creative biogene Category siRNA Species Reactivities Human

Human KYNU siRNA - orb266417 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

KYNU shRNA Plasmid (Human) - CHH5915 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

KYNU miRNA 3'UTR clone - MiUTR1H-05544 from Creative biogene Species Reactivities Human

KYNU miRNA 3'UTR clone - MiUTR1H-05545 from Creative biogene Species Reactivities Human

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