ABCG1
| Gene Symbol | ABCG1 |
|---|---|
| Entrez Gene | 9619 |
| Alt Symbol | ABC8, WHITE1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP-binding cassette, sub-family G (WHITE), member 1 |
| Other Description | ABC transporter 8|ATP-binding cassette sub-family G member 1|ATP-binding cassette transporter 8|ATP-binding cassette transporter member 1 of subfamily G|homolog of Drosophila white|white protein homolog (ATP-binding cassette transporter 8) |
| Swissprots | Q9BXK9 Q9BXK7 Q9BXL2 Q96L76 Q9BXL3 Q86SU8 Q9BXK8 Q9BXL0 Q9BXL4 P45844 Q9BXL1 Q9BXK6 |
| Accessions | AAK28833 AAK28834 AAK28835 AAK28836 AAK28837 BAA95530 BAB13728 CAC00730 EAX09574 EAX09575 P45844 AF038175 AAB97364 AF086547 AF323660 AAK28838 AF323661 AAK28839 AF323662 AAK28840 AF323663 AAK28841 AF323664 AAK28842 AK092959 AK292152 BAF84841 AK298491 BAG60699 AL355688 AL355711 AL833689 AY048757 AAL06598 BC029158 AAH29158 BX537588 DQ891343 ABM82269 EU176570 ABW03371 EU832827 ACE87838 GQ129336 ACT64470 X91249 CAA62631 XM_011529806 XP_011528108 XM_011529807 XP_011528109 NM_004915 NP_004906 NM_016818 NP_058198 NM_207174 NP_997057 NM_207627 NP_997510 NM_207628 NP_997511 NM_207629 NP_997512 NM_207630 |
| Function | Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:22042635}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269|PubMed:22042635}. Golgi apparatus membrane {ECO:0000269|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269|PubMed:22042635}. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes. |
| Tissue Specificity | Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease. {ECO:0000269|PubMed:11350058}. |
| Top Pathways | ABC transporters |
ABCG1 CRISPR/Cas9 KO Plasmid (h) - sc-401237 from Santa Cruz Biotechnology
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ABCG1 HDR Plasmid (h) - sc-401237-HDR from Santa Cruz Biotechnology
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ABCG1 Double Nickase Plasmid (h) - sc-401237-NIC from Santa Cruz Biotechnology
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ABCG1 Double Nickase Plasmid (h2) - sc-401237-NIC-2 from Santa Cruz Biotechnology
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ABCG1 CRISPR Activation Plasmid (h) - sc-401237-ACT from Santa Cruz Biotechnology
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ABCG1 CRISPR Activation Plasmid (h2) - sc-401237-ACT-2 from Santa Cruz Biotechnology
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ABCG1 Lentiviral Activation Particles (h) - sc-401237-LAC from Santa Cruz Biotechnology
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ABCG1 Lentiviral Activation Particles (h2) - sc-401237-LAC-2 from Santa Cruz Biotechnology
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ABCG1 siRNA (h) - sc-41138 from Santa Cruz Biotechnology
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ABC8 shRNA Plasmid (h) - sc-41138-SH from Santa Cruz Biotechnology
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ABC8 shRNA (h) Lentiviral Particles - sc-41138-V from Santa Cruz Biotechnology
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ABCG1 RNAi - H00009619-R11 from Novus Biologicals
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ABCG1 RNAi - H00009619-R14 from Novus Biologicals
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ABCG1 RNAi - H00009619-R08 from Novus Biologicals
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ABCG1 RNAi - H00009619-R13 from Novus Biologicals
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MISSION® esiRNA - EHU064371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1202 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1202 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1203 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07373 from Sigma-Aldrich
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ABCG1 siRNA (Human) - CRH6401 from Cohesion Biosciences
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ABCG1 RNAi - H00009619-R10 from Novus Biologicals
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ABCG1 RNAi - H00009619-R09 from Novus Biologicals
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ABCG1 RNAi - H00009619-R12 from Novus Biologicals
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ABCG1 - MBS8214950 from MyBioSource
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