| Gene Symbol |
Dgcr8
|
| Entrez Gene |
94223
|
| Alt Symbol |
D16H22S1742E, D16H22S788E, D16Wis2, Gy1, N41, Vo59c07, mir-1306
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
DiGeorge syndrome critical region gene 8
|
| Other Description |
diGeorge syndrome critical region 8 homolog|microprocessor complex subunit DGCR8
|
| Swissprots |
Q9EQM6
|
| Accessions |
EDK97512 EDK97513 EDK97514 EDK97515 Q9EQM6 AB086857 BAD06468 AF201683 AAG35599 AK044890 AK048056 AK054321 AK086233 AK161410 AK180426 BC051013 BC062919 AAH62919 BC066118 AAH66118 LM610470 XM_006522795 XP_006522858 XM_006536876 XP_006536939 XM_006544951 XP_006545014 XM_011246056 XP_011244358 XM_011246057 XP_011244359 XM_011246058 XP_011244360 XM_011251445 XP_011249747 XM_011251446 XP_011249748 XM_011251447 XP_011249749 XM_011251524 XP_011249826 XM_011251525 XP_011249827 XM_011251526 XP_011249828 NM_033324 NP_201581
|
| Function |
Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri- miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri- miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (By similarity). Involved in the silencing of embryonic stem
|
| Subcellular Location |
Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:12705904}.
|