Dgcr8

Gene Symbol Dgcr8
Entrez Gene 94223
Alt Symbol D16H22S1742E, D16H22S788E, D16Wis2, Gy1, N41, Vo59c07, mir-1306
Species Mouse
Gene Type protein-coding
Description DiGeorge syndrome critical region gene 8
Other Description diGeorge syndrome critical region 8 homolog|microprocessor complex subunit DGCR8
Swissprots Q9EQM6
Accessions EDK97512 EDK97513 EDK97514 EDK97515 Q9EQM6 AB086857 BAD06468 AF201683 AAG35599 AK044890 AK048056 AK054321 AK086233 AK161410 AK180426 BC051013 BC062919 AAH62919 BC066118 AAH66118 LM610470 XM_006522795 XP_006522858 XM_006536876 XP_006536939 XM_006544951 XP_006545014 XM_011246056 XP_011244358 XM_011246057 XP_011244359 XM_011246058 XP_011244360 XM_011251445 XP_011249747 XM_011251446 XP_011249748 XM_011251447 XP_011249749 XM_011251524 XP_011249826 XM_011251525 XP_011249827 XM_011251526 XP_011249828 NM_033324 NP_201581
Function Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri- miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri- miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (By similarity). Involved in the silencing of embryonic stem
Subcellular Location Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:12705904}.

DGCR8 CRISPR/Cas9 KO Plasmid (m) - sc-430139 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DGCR8 HDR Plasmid (m) - sc-430139-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DGCR8 Double Nickase Plasmid (m) - sc-430139-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DGCR8 Double Nickase Plasmid (m2) - sc-430139-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DGCR8 CRISPR Activation Plasmid (m) - sc-430139-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DGCR8 CRISPR Activation Plasmid (m2) - sc-430139-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DGCR8 Lentiviral Activation Particles (m) - sc-430139-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DGCR8 Lentiviral Activation Particles (m2) - sc-430139-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

DGS8 siRNA (m) - sc-60530 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

DGS8 shRNA Plasmid (m) - sc-60530-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

DGS8 shRNA (m) Lentiviral Particles - sc-60530-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU000781 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN29942 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29942 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DGCR8 siRNA (Mouse) - CRN0325 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

DGCR8 - MBS8226149 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse DGCR (NM_033324.2) - SHH277384 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Dgcr8(NM_033324.2) - SHH002711 from Creative biogene

Category siRNA
Species Reactivities Mouse

DGCR8 shRNA Plasmid (Mouse) - CHN0325 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

DGCR8 miRNA 3'UTR clone - MiUTR1M-03827 from Creative biogene

Species Reactivities Mouse
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