| Gene Symbol |
B3GAT1
|
| Entrez Gene |
27087
|
| Alt Symbol |
CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
beta-1,3-glucuronyltransferase 1
|
| Other Description |
LEU7 antigen|UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1|glcUAT-P|glucuronosyltransferase P
|
| Swissprots |
Q96FS7 Q9P2W7
|
| Accessions |
Q9P2W7 AB029396 BAA96077 AF131769 AK299637 BAH13084 AL834455 CAD39115 BC010466 AAH10466 CR457098 CAG33379 DQ893324 ABM84250 DQ895278 ABM86204 DQ896640 ABM87639 XM_005271506 XP_005271563 XM_005271508 XP_005271565 XM_011542751 XP_011541053 XM_011542752 XP_011541054 XM_011542753 XP_011541055 XM_011542754 XP_011541056 XM_011542755 XP_011541057 NM_018644 NP_061114 NM_054025 NP_473366
|
| Function |
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Mainly expressed in the brain.
|
| Top Pathways |
Other types of O-glycan biosynthesis
|