| Gene Symbol | B3GAT1 |
|---|---|
| Entrez Gene | 27087 |
| Alt Symbol | CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | beta-1,3-glucuronyltransferase 1 |
| Other Description | LEU7 antigen|UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1|glcUAT-P|glucuronosyltransferase P |
| Swissprots | Q96FS7 Q9P2W7 |
| Accessions | Q9P2W7 AB029396 BAA96077 AF131769 AK299637 BAH13084 AL834455 CAD39115 BC010466 AAH10466 CR457098 CAG33379 DQ893324 ABM84250 DQ895278 ABM86204 DQ896640 ABM87639 XM_005271506 XP_005271563 XM_005271508 XP_005271565 XM_011542751 XP_011541053 XM_011542752 XP_011541054 XM_011542753 XP_011541055 XM_011542754 XP_011541056 XM_011542755 XP_011541057 NM_018644 NP_061114 NM_054025 NP_473366 |
| Function | Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity). {ECO:0000250}. |
| Subcellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Mainly expressed in the brain. |
| Top Pathways | Other types of O-glycan biosynthesis |
CD57 CRISPR/Cas9 KO Plasmid (h) - sc-402750 from Santa Cruz Biotechnology
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CD57 HDR Plasmid (h) - sc-402750-HDR from Santa Cruz Biotechnology
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CD57 Double Nickase Plasmid (h) - sc-402750-NIC from Santa Cruz Biotechnology
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CD57 Double Nickase Plasmid (h2) - sc-402750-NIC-2 from Santa Cruz Biotechnology
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CD57 CRISPR Activation Plasmid (h) - sc-402750-ACT from Santa Cruz Biotechnology
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CD57 CRISPR Activation Plasmid (h2) - sc-402750-ACT-2 from Santa Cruz Biotechnology
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CD57 Lentiviral Activation Particles (h) - sc-402750-LAC from Santa Cruz Biotechnology
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CD57 Lentiviral Activation Particles (h2) - sc-402750-LAC-2 from Santa Cruz Biotechnology
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CD57 siRNA (h) - sc-42798 from Santa Cruz Biotechnology
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CD57 shRNA Plasmid (h) - sc-42798-SH from Santa Cruz Biotechnology
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CD57 shRNA (h) Lentiviral Particles - sc-42798-V from Santa Cruz Biotechnology
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beta-1,3-Glucuronyltransferase 1/B3GAT1 RNAi - H00027087-R01 from Novus Biologicals
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MISSION® esiRNA - EHU091661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3802 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3802 from Sigma-Aldrich
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B3GAT1 siRNA (Human) - CRH8955 from Cohesion Biosciences
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beta-1,3-Glucuronyltransferase 1/B3GAT1 RNAi - H00027087-R02 from Novus Biologicals
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B3GAT1 - MBS8223157 from MyBioSource
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shRNA set against Human B3GAT1 (NM_018644.3) - SHH244194 from Creative biogene
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shRNA set against Human B3GAT1(NM_018644.3) - SHG088703 from Creative biogene
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B3GAT1 shRNA Plasmid (Human) - CHH8955 from Cohesion Biosciences
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B3GAT1 miRNA 3'UTR clone - MiUTR1H-00766 from Creative biogene
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