| Gene Symbol |
SRRT
|
| Entrez Gene |
51593
|
| Alt Symbol |
ARS2, ASR2, serrate
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serrate, RNA effector molecule
|
| Other Description |
arsenate resistance protein 2|arsenate resistance protein ARS2|arsenite resistance protein|arsenite-resistance protein 2|serrate RNA effector molecule homolog
|
| Swissprots |
Q32MI4 A6NK22 Q6NT74 Q9BWP6 A4D2E6 Q9BXP4 B4DZA6 A4D2E5 Q9Y4S4 Q9BXP5 Q8TDQ5 B4DJL4 O95808
|
| Accessions |
AAG24951 AAK21005 AAK21006 EAL23815 EAL23816 EAW76465 EAW76466 EAW76467 Q9BXP5 AF082871 AAD17774 AF112994 AAP97227 AF248955 AAM00189 AK296131 BAG58876 AK302820 BAG64018 AK311728 AL096723 CAB46374 AW770857 BC000082 AAH00082 BC069249 AAH69249 BC109116 BC109117 AAI09118 BE247268 BE297447 BF515651 BG477711 BG685713 BQ059529 DA611314 XM_005250405 XP_005250462 XM_005250406 XP_005250463 XM_005250407 XP_005250464 XM_005250408 XP_005250465 XM_006716023 XP_006716086 XM_011516291 XP_011514593 NM_182800 NM_001128852 NP_001122324 NM_001128853 NP_001122325 NM_001128854 NP_001122326 NM_015908 NP_056992
|
| Function |
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:18086880}.
|