KMT2E

Gene Symbol KMT2E
Entrez Gene 55904
Alt Symbol HDCMC04P, MLL5, NKp44L
Species Human
Gene Type protein-coding
Description lysine (K)-specific methyltransferase 2E
Other Description histone-lysine N-methyltransferase 2E|histone-lysine N-methyltransferase MLL5|myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)|myeloid/lymphoid or mixed-lineage leukemia protein 5
Swissprots Q9NWE7 Q6PKG4 B6ZDE4 Q86WG0 Q86TI3 M4K8J3 B6ZDM3 Q8IZD2 Q6P5Y2 Q8IWR5 Q8IV78 Q8NFF8 Q86W12 Q86WL2 Q6T316
Accessions AAD04721 EAW83355 EAW83356 EAW83357 EAW83358 Q8IZD2 AF067804 AAF75564 AF519459 AAM74947 AK000940 AK024088 BAB14821 AY113691 AY147037 AAN17675 AY157990 AAN76325 AY195568 AAO47009 AY195569 AAO47010 AY211525 AAO86416 AY222296 AAO64395 AY234382 AAO89072 AY438698 AAR13893 AY438699 AAR13894 BC001296 AAH01296 BC009061 BC016382 BC024658 BC040004 AAH40004 BC040848 BC053906 AAH53906 BC062583 AAH62583 BC142987 AAI42988 JQ809698 AGE34449 XM_005250493 XP_005250550 XM_006716049 XP_006716112 XM_011516400 XP_011514702 XR_927489 NM_018682 NP_061152 NM_182931 NP_891847 NM_032187
Function Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic- acid-induced granulopoiesis by acting as a coactivator of RAR- alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.
Subcellular Location Nucleus speckle {ECO:0000269|PubMed:14718661}. Note=Absent from the nucleolus. {ECO:0000269|PubMed:14718661}.
Tissue Specificity Widely expressed in both adult and fetal tissues. Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum. Isoform NKp44L is not detected on circulating cells from healthy individuals, but it is expressed on a large panel of the tumor and transformed cells. {ECO:0000269|PubMed:12101424, ECO:0000269|PubMed:23958951}.
Top Pathways Lysine degradation

MLL5 CRISPR/Cas9 KO Plasmid (h) - sc-403300 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL5 HDR Plasmid (h) - sc-403300-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL5 Double Nickase Plasmid (h) - sc-403300-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL5 Double Nickase Plasmid (h2) - sc-403300-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL5 CRISPR Activation Plasmid (h) - sc-403300-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL5 CRISPR Activation Plasmid (h2) - sc-403300-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL5 Lentiviral Activation Particles (h) - sc-403300-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL5 Lentiviral Activation Particles (h2) - sc-403300-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL5 siRNA (h) - sc-75798 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLL5 shRNA Plasmid (h) - sc-75798-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLL5 shRNA (h) Lentiviral Particles - sc-75798-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLL5 RNAi - H00055904-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MLL5 RNAi - H00055904-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU094211 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14400 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14400 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

KMT2E siRNA (Human) - CRJ1003 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MLL5 (NM_182931.2) - SHH342552 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MLL5(NM_018682.3) - SHH192071 from Creative biogene

Category siRNA
Species Reactivities Human

Human KMT2E siRNA - orb271504 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KMT2E shRNA Plasmid (Human) - CHJ1003 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MLL5 miRNA 3'UTR clone - MiUTR1H-06326 from Creative biogene

Species Reactivities Human

MLL5 miRNA 3'UTR clone - MiUTR3H-10010 from Creative biogene

Species Reactivities Human
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