| Gene Symbol | ATP6V1H |
|---|---|
| Entrez Gene | 51606 |
| Alt Symbol | CGI-11, MSTP042, NBP1, SFD, SFDalpha, SFDbeta, VMA13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H |
| Other Description | V-ATPase 50/57 kDa subunits|V-ATPase subunit H|V-type proton ATPase subunit H|nef-binding protein 1|protein VMA13 homolog|vacuolar ATP synthase subunit H|vacuolar ATPase subunit H|vacuolar proton pump subunit H|vacuolar proton pump subunit SFD |
| Swissprots | B3KMR0 Q6PK44 Q9UI12 Q9Y300 Q9H3E3 |
| Accessions | CAE90355 EAW86727 EAW86728 EAW86729 EAW86730 EAW86731 EAW86732 EAW86733 Q9UI12 AF112204 AAF17192 AF113222 AAG39293 AF125105 AAL75942 AF132945 AAD27720 AF298777 AAG22809 AI741756 AK022345 BAG51072 AK094839 AK098305 BAG53609 AK303229 BAG64316 AK308204 AL598970 BC007421 BC007454 BC014862 BC025275 AAH25275 BG197001 DA147153 DB464555 XM_006716455 XP_006716518 XM_011517542 XP_011515844 NM_015941 NP_057025 NM_213619 NP_998784 NM_213620 NP_998785 |
| Function | Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. {ECO:0000250}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9620685}. |
| Top Pathways | Tuberculosis, Synaptic vesicle cycle, Rheumatoid arthritis, Phagosome, Lysosome |