| Gene Symbol |
CEACAM3
|
| Entrez Gene |
1084
|
| Alt Symbol |
CD66D, CEA, CGM1, W264, W282
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carcinoembryonic antigen-related cell adhesion molecule 3
|
| Other Description |
CD66d antigen|carcinoembryonic antigen CGM1|carcinoembryonic antigen gene family member 1|nonspecific cross-reacting antigen
|
| Swissprots |
Q3KPH9 G5E978 P40198
|
| Accessions |
AAA51965 CAA34473 EAW57062 EAW57063 EAW57064 EAW57065 P40198 AK298694 BAH12850 BC106728 AAI06729 D90277 BAA14321 D90278 BAA14322 DA674909 DC428993 E03348 E03349 L00692 AAA51969 L00693 AAA51970 NM_001277163 NP_001264092 NM_001815 NP_001806 NR_102333
|
| Function |
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. {ECO:0000269|PubMed:12864848, ECO:0000269|PubMed:14707113}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. {ECO:0000269|PubMed:11708798}.
|