Gene Symbol | INPP5J |
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Entrez Gene | 27124 |
Alt Symbol | INPP5, PIB5PA, PIPP |
Species | Human |
Gene Type | protein-coding |
Description | inositol polyphosphate-5-phosphatase J |
Other Description | inositol polyphosphate 5-phosphatase J|phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A|phosphatidylinositol 4,5-bisphosphate 5-phosphatase A |
Swissprots | Q6ZTH6 Q15735 Q8N902 Q32M61 B3KS54 Q9UDT9 |
Accessions | AAD15618 EAW59936 EAW59937 EAW59938 EAW59939 EAW59940 Q15735 AK092859 BAG52616 AK095944 BAC04657 AK126610 BAC86611 AK293992 BAG57356 AK308921 AK309548 AW014134 BC041652 BC109288 AAI09289 BU507439 BU584792 U45975 AAB03216 XM_011530143 XP_011528445 NM_014422 NM_001002837 NP_001002837 NM_001284285 NP_001271214 NM_001284286 NP_001271215 NM_001284287 NP_001271216 NM_001284288 NP_001271217 NM_001284289 NP_001271218 |
Function | Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Note=Predominantly localized to membrane ruffles. {ECO:0000250}. |
Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |
INPP5J CRISPR/Cas9 KO Plasmid (h) - sc-408431 from Santa Cruz Biotechnology
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INPP5J HDR Plasmid (h) - sc-408431-HDR from Santa Cruz Biotechnology
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INPP5J Double Nickase Plasmid (h) - sc-408431-NIC from Santa Cruz Biotechnology
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INPP5J Double Nickase Plasmid (h2) - sc-408431-NIC-2 from Santa Cruz Biotechnology
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INPP5J CRISPR Activation Plasmid (h) - sc-408431-ACT from Santa Cruz Biotechnology
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INPP5J CRISPR Activation Plasmid (h2) - sc-408431-ACT-2 from Santa Cruz Biotechnology
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INPP5J Lentiviral Activation Particles (h) - sc-408431-LAC from Santa Cruz Biotechnology
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INPP5J Lentiviral Activation Particles (h2) - sc-408431-LAC-2 from Santa Cruz Biotechnology
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INPP5J siRNA (h) - sc-76130 from Santa Cruz Biotechnology
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INPP5J shRNA Plasmid (h) - sc-76130-SH from Santa Cruz Biotechnology
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INPP5J shRNA (h) Lentiviral Particles - sc-76130-V from Santa Cruz Biotechnology
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PIB5PA RNAi - H00027124-R01 from Novus Biologicals
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PIB5PA RNAi - H00027124-R02 from Novus Biologicals
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MISSION® esiRNA - EHU057711 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0425 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0426 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0424 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10695 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10695 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02325 from Sigma-Aldrich
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INPP5J siRNA (Human) - CRH8978 from Cohesion Biosciences
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INPP5J - MBS8213250 from MyBioSource
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shRNA set against Human INPP5J (NM_001002837.1) - SHH319753 from Creative biogene
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shRNA set against Human PIB5PA(NM_001002837.1) - SHR113244 from Creative biogene
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INPP5J shRNA Plasmid (Human) - CHH8978 from Cohesion Biosciences
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