| Gene Symbol | ENTPD1 |
|---|---|
| Entrez Gene | 953 |
| Alt Symbol | ATPDase, CD39, NTPDase-1, SPG64 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ectonucleoside triphosphate diphosphohydrolase 1 |
| Other Description | CD39 antigen|NTPDase 1|ecto-ATP diphosphohydrolase 1|ecto-ATPDase 1|ecto-ATPase 1|ecto-apyrase|lymphoid cell activation antigen |
| Swissprots | Q5T561 A9Z1X8 G3XAF6 B7Z599 B4E1X1 Q5T562 P49961 B4DWB9 Q86VV3 Q9Y3Q9 Q9UQQ9 |
| Accessions | CCQ43149 EAW49987 EAW49988 EAW49989 EAW49990 EAW49991 P49961 AJ133133 CAB41886 AJ133134 CAB41887 AK098240 AK098278 AK298648 BAH12835 AK301459 BAG62981 AK304018 BAG64933 AK304836 BAG65580 AK316009 BAH14380 AL547722 AL833543 BC047664 AAH47664 BF839210 BX537522 CD652289 DC423382 S73813 AAB32152 U87967 AAB47572 XM_011540370 XP_011538672 XM_011540371 XP_011538673 XM_011540372 XP_011538674 XM_011540373 XP_011538675 XM_011540374 XP_011538676 XM_011540375 XP_011538677 XM_011540376 XP_011538678 XM_011540377 XP_011538679 NM_001098175 NP_001091645 NM_001164178 NP_001157650 NM_001164179 NP_001157651 NM_001164181 NP_001157653 NM_001164182 NP_001157654 NM_001164183 NP_001157655 NM_001776 NP_001767 |
| Function | In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. {ECO:0000269|PubMed:8955160}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only. |
| Top Pathways | Epstein-Barr virus infection, Purine metabolism, Pyrimidine metabolism |