Gene Symbol | SEC61A2 |
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Entrez Gene | 55176 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | Sec61 alpha 2 subunit (S. cerevisiae) |
Other Description | Sec61 alpha form 2|protein transport protein Sec61 subunit alpha|protein transport protein Sec61 subunit alpha isoform 2|sec61 alpha-2 |
Swissprots | F8W773 B4DX72 A8K8D0 Q9H9S3 |
Accessions | EAW86323 EAW86324 EAW86325 EAW86326 Q9H9S3 AF346603 AAK29084 AK001440 BAA91692 AK022027 BAB13955 AK022640 BAB14148 AK057532 BAG51930 AK292295 BAF84984 AK301841 BAG63284 BC026179 AAH26179 BP212860 BX645143 JF432518 ADZ15735 NM_001142627 NP_001136099 NM_001142628 NP_001136100 NM_018144 NP_060614 NR_024576 NR_024577 |
Function | Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | Protein export, Vibrio cholerae infection, Phagosome, Protein processing in endoplasmic reticulum |
Sec61α2 CRISPR/Cas9 KO Plasmid (h) - sc-402223 from Santa Cruz Biotechnology
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Sec61α2 HDR Plasmid (h) - sc-402223-HDR from Santa Cruz Biotechnology
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Sec61α2 Double Nickase Plasmid (h) - sc-402223-NIC from Santa Cruz Biotechnology
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Sec61α2 Double Nickase Plasmid (h2) - sc-402223-NIC-2 from Santa Cruz Biotechnology
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Sec61α2 CRISPR Activation Plasmid (h) - sc-402223-ACT from Santa Cruz Biotechnology
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Sec61α2 CRISPR Activation Plasmid (h2) - sc-402223-ACT-2 from Santa Cruz Biotechnology
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Sec61α2 Lentiviral Activation Particles (h) - sc-402223-LAC from Santa Cruz Biotechnology
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Sec61α2 Lentiviral Activation Particles (h2) - sc-402223-LAC-2 from Santa Cruz Biotechnology
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Sec61α2 siRNA (h) - sc-106541 from Santa Cruz Biotechnology
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Sec61α2 shRNA Plasmid (h) - sc-106541-SH from Santa Cruz Biotechnology
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Sec61α2 shRNA (h) Lentiviral Particles - sc-106541-V from Santa Cruz Biotechnology
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SEC61A2 RNAi - H00055176-R01 from Novus Biologicals
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MISSION® esiRNA - EHU087221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19040 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19040 from Sigma-Aldrich
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SEC61A2 siRNA (Human) - CRJ0529 from Cohesion Biosciences
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SEC61A2 - MBS8208280 from MyBioSource
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shRNA set against Human SEC61A2 (NM_018144.3) - SHH403892 from Creative biogene
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Human SEC61A2 siRNA - orb271030 from Biorbyt
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SEC61A2 shRNA Plasmid (Human) - CHJ0529 from Cohesion Biosciences
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SEC61A2 miRNA 3'UTR clone - MiUTR3H-16034 from Creative biogene
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SEC61A2 miRNA 3'UTR clone - MiUTR3H-16035 from Creative biogene
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SEC61A2 miRNA 3'UTR clone - MiUTR3H-16036 from Creative biogene
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