| Gene Symbol | FGG |
|---|---|
| Entrez Gene | 2266 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | fibrinogen gamma chain |
| Other Description | fibrinogen, gamma polypeptide |
| Swissprots | Q9UC62 Q96A14 Q9UC63 Q9UCF3 A8K057 Q53Y18 P02679 P04470 P04469 Q96KJ3 |
| Accessions | AAA52430 AAA52431 AAB59530 AAB59531 AAK19751 AAK19752 CDL78904 EAX04905 EAX04906 EAX04907 EAX04908 EAX04909 EAX04910 EAX04911 EAX04912 EAX04913 EAX04914 EAX04915 EAX04916 EAX04917 EAX04918 EAX04919 EAX04920 EAX04921 EAX04922 EAX04923 P02679 AA936960 AI808530 AK289422 BAF82111 AK290824 BAF83513 AL531173 BC007044 AAH07044 BC021674 AAH21674 BG567044 BT007081 AAP35744 BX538098 CAD98014 X00086 CAA24944 X51473 CAA35837 NM_000509 NP_000500 NM_021870 NP_068656 |
| Function | Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| Subcellular Location | Secreted. |
| Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection |