| Function |
Antitoxin component of a toxin-antitoxin (TA) module which inhibits the post-segregational killing (PSK) of plasmid- free cells, also referred to as a plasmid addiction system. Labile antitoxin with a half-life of about 1 hour in the presence of CcdB. Binds to and blocks the activity of CcdB; will also remove bound CcdB protein from the CcdB-GyrA complex by forming a CcdA- CcdB complex, a process termed rejuvenation. The N-terminal 36 residues are not required for rejuventation. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdB. {ECO:0000269|PubMed:1324324, ECO:0000269|PubMed:19647513, ECO:0000269|PubMed:2615761, ECO:0000269|PubMed:2651399, ECO:0000269|PubMed:6308648, ECO:0000269|PubMed:6327993, ECO:0000269|PubMed:8604132}.
|