| Gene Symbol |
Aox4
|
| Entrez Gene |
71872
|
| Alt Symbol |
2310003G12Rik, Aoh2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
aldehyde oxidase 4
|
| Other Description |
aldehyde oxidase homolog 2|aldehyde oxidase structural homolog 2|azaheterocycle hydroxylase 4|retinal oxidase
|
| Swissprots |
Q8VI17 Q3TYQ9
|
| Accessions |
AAL38126 EDL00070 Q3TYQ9 AF233581 AAF98385 AI414378 AK009112 AK081746 AK081936 AK158427 BAE34503 AK160953 BC117975 AAI17976 BC117976 AAI17977 XM_006496286 XP_006496349 XM_006496287 XP_006496350 XM_006496288 XP_006496351 NM_023631 NP_076120
|
| Function |
Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all- trans-retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles. {ECO:0000269|PubMed:18981221}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18981221}.
|
| Tissue Specificity |
Highly expressed in Harderian glands and sebaceous glands with detectable levels in the epidermis and other keratinized epithelia (at protein level). Detected in testis. The expression is 3 times greater in females than in males. {ECO:0000269|PubMed:18981221, ECO:0000269|PubMed:23263164}.
|
| Top Pathways |
Tyrosine metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism, Tryptophan metabolism
|