| Gene Symbol | SLC11A1 |
|---|---|
| Entrez Gene | 396764 |
| Alt Symbol | NRAMP1 |
| Species | Pig |
| Gene Type | protein-coding |
| Description | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 |
| Other Description | NRAMP 1|natural resistance-associated macrophage protein 1|solute carrier family 11 member 1 |
| Swissprots | O77741 Q9N1Y2 |
| Accessions | AAQ94003 AAQ94004 AAQ94005 AAQ94006 AAQ94007 AAQ94008 AAQ94009 AAQ94010 AAQ94011 AAQ94012 AAQ94013 AAQ94014 AAQ94015 O77741 AF132037 AAF36527 AK232181 AK236615 AK397833 U55068 AAC24491 NM_213821 NP_998986 |
| Function | Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Top Pathways | Lysosome, Mineral absorption |