Gene Symbol | Cd40lg |
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Entrez Gene | 21947 |
Alt Symbol | CD154, CD40-L, Cd40l, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, TRAP, Tnfsf5, gp39 |
Species | Mouse |
Gene Type | protein-coding |
Description | CD40 ligand |
Other Description | T-cell antigen Gp39|TNF-related activation protein|tumor necrosis factor ligand superfamily member 5 |
Swissprots | P27548 |
Accessions | AAC13639 AAC13640 CAL44886 CBY45345 EDL42166 P27548 BC119225 AAI19226 EU274582 ABX76043 X65453 CAA46448 NM_011616 NP_035746 |
Function | Cytokine that binds to TNFRSF5. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type II membrane protein. |
Tissue Specificity | Specifically expressed on activated CD4+ T- lymphocytes. |
Top Pathways | Cytokine-cytokine receptor interaction, Primary immunodeficiency, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production |
CD154 CRISPR/Cas9 KO Plasmid (m) - sc-423452 from Santa Cruz Biotechnology
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CD154 HDR Plasmid (m) - sc-423452-HDR from Santa Cruz Biotechnology
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CD154 Double Nickase Plasmid (m) - sc-423452-NIC from Santa Cruz Biotechnology
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CD154 Double Nickase Plasmid (m2) - sc-423452-NIC-2 from Santa Cruz Biotechnology
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CD154 CRISPR Activation Plasmid (m) - sc-423452-ACT from Santa Cruz Biotechnology
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CD154 CRISPR Activation Plasmid (m2) - sc-423452-ACT-2 from Santa Cruz Biotechnology
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CD154 Lentiviral Activation Particles (m) - sc-423452-LAC from Santa Cruz Biotechnology
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CD154 Lentiviral Activation Particles (m2) - sc-423452-LAC-2 from Santa Cruz Biotechnology
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CD154 siRNA (m) - sc-29966 from Santa Cruz Biotechnology
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CD154 shRNA Plasmid (m) - sc-29966-SH from Santa Cruz Biotechnology
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CD154 shRNA (m) Lentiviral Particles - sc-29966-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN28364 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28364 from Sigma-Aldrich
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CD40LG siRNA (Mouse) - CRM4194 from Cohesion Biosciences
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CD40LG - MBS8205854 from MyBioSource
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shRNA set against Mouse CD40LG (NM_011616.2) - SHH259121 from Creative biogene
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shRNA set against Mouse Cd40lg(NM_011616.2) - SHG157447 from Creative biogene
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CD40LG shRNA Plasmid (Mouse) - CHM4194 from Cohesion Biosciences
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CD40LG miRNA 3'UTR clone - MiUTR1M-02773 from Creative biogene
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