Gene Symbol | UFM1 |
---|---|
Entrez Gene | 51569 |
Alt Symbol | BM-002, C13orf20 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin-fold modifier 1 |
Other Description | - |
Swissprots | P61960 Q5VXS0 Q6IAG6 |
Accessions | EAX08605 P61960 AB154404 BAD15373 AF208844 AAF64258 AF369953 AK095490 AK307111 AK309914 AL515797 BC005193 AAH05193 BG533062 BG540094 BG717690 BI458294 BI761948 BM683574 BP277186 BQ002588 BU069122 BU589105 CB070175 CN362375 CR457189 CAG33470 DA448931 DA483023 JF432449 ADZ15666 Z70222 CAA94181 NM_001286703 NP_001273632 NM_001286704 NP_001273633 NM_001286705 NP_001273634 NM_001286706 NP_001273635 NM_016617 NP_057701 NR_104584 NR_104585 |
Function | Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:P61961, ECO:0000269|PubMed:15071506, ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:25219498}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15071506}. Cytoplasm {ECO:0000269|PubMed:15071506}. |
UFM1 CRISPR/Cas9 KO Plasmid (h) - sc-416900 from Santa Cruz Biotechnology
|
||||||||
UFM1 HDR Plasmid (h) - sc-416900-HDR from Santa Cruz Biotechnology
|
||||||||
UFM1 Double Nickase Plasmid (h) - sc-416900-NIC from Santa Cruz Biotechnology
|
||||||||
UFM1 Double Nickase Plasmid (h2) - sc-416900-NIC-2 from Santa Cruz Biotechnology
|
||||||||
UFM1 CRISPR Activation Plasmid (h) - sc-416900-ACT from Santa Cruz Biotechnology
|
||||||||
UFM1 CRISPR Activation Plasmid (h2) - sc-416900-ACT-2 from Santa Cruz Biotechnology
|
||||||||
UFM1 Lentiviral Activation Particles (h) - sc-416900-LAC from Santa Cruz Biotechnology
|
||||||||
UFM1 Lentiviral Activation Particles (h2) - sc-416900-LAC-2 from Santa Cruz Biotechnology
|
||||||||
UFM1 siRNA (h) - sc-76804 from Santa Cruz Biotechnology
|
||||||||
UFM1 shRNA Plasmid (h) - sc-76804-SH from Santa Cruz Biotechnology
|
||||||||
UFM1 shRNA (h) Lentiviral Particles - sc-76804-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU008421 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN22448 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22448 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR11212 from Sigma-Aldrich
|
||||||||
UFM1 siRNA (Human) - CRH9838 from Cohesion Biosciences
|
||||||||
UFM1 - MBS8236491 from MyBioSource
|
||||||||
shRNA set against Human UFM1 (NM_016617.2) - SHH439948 from Creative biogene
|
||||||||
Human UFM1 siRNA - orb270340 from Biorbyt
|
||||||||
UFM1 shRNA Plasmid (Human) - CHH9838 from Cohesion Biosciences
|
||||||||
UFM1 miRNA 3'UTR clone - MiUTR4H-TG09643 from Creative biogene
|