BUB3

Gene Symbol	BUB3
Entrez Gene	9184
Alt Symbol	BUB3L, hBUB3
Species	Human
Gene Type	protein-coding
Description	BUB3 mitotic checkpoint protein
Other Description	BUB3 budding uninhibited by benzimidazoles 3 homolog|budding uninhibited by benomyl|budding uninhibited by benzimidazoles 3 homolog|mitotic checkpoint component|mitotic checkpoint protein BUB3
Swissprots	O43684 O43685 B2R6E7 A6NJ42 D3DRE9
Accessions	AAL17976 EAW49284 EAW49285 EAW49286 EAW49287 O43684 AF047472 AAC28438 AF047473 AAC28439 AF053304 AAC06258 AF081496 AAC36307 AK226060 AK293255 BAG56787 AK307958 AK312546 BAG35444 BC005138 AAH05138 BC022438 AAH22438 BM989334 BP328027 BU932619 BX647392 DQ891852 ABM82778 DQ895042 ABM85968 NM_001007793 NP_001007794 NM_004725 NP_004716
Function	Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:18199686}.
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. {ECO:0000250}.
Top Pathways	Cell cycle, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BUB 3 Gene - orb91780 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-BUB3-cDNA-Clone - DC05254 from Abgent, a WuXi AppTec company Prices $442.80 Sizes 10 µg Species Human Accession BC005138

BUB3 - MBS1275811 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC022438

BUB3 - MBS1267126 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC005138

Human BUB3 Gene ORF cDNA clone in cloning vector - HG11236-M from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11236-CY from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid - HG11236-UT from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11236-ACR from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11236-ANR from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11236-NF from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11236-NM from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11236-ANG from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11236-CF from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11236-NY from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11236-CM from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, N-His tag - HG11236-NH from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, C-His tag - HG11236-CH from Sino Biological Species Human

Human BUB3 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11236-ACG from Sino Biological Species Human

BUB3 - CL01271H01 from Elabscience Species Human Accession NM_004725.3

Human BUB3 ORF clone(NM_004725.3) - CDCL182940 from Creative biogene Species Human

Human BUB3 ORF Clone (BC005138) - CDCS406341 from Creative biogene Species Human Accession O43684

Human BUB3 ORF Clone (BC022438) - CDCS406342 from Creative biogene Species Human Accession O43684

Search more