BUB3

Gene Symbol	BUB3
Entrez Gene	9184
Alt Symbol	BUB3L, hBUB3
Species	Human
Gene Type	protein-coding
Description	BUB3 mitotic checkpoint protein
Other Description	BUB3 budding uninhibited by benzimidazoles 3 homolog|budding uninhibited by benomyl|budding uninhibited by benzimidazoles 3 homolog|mitotic checkpoint component|mitotic checkpoint protein BUB3
Swissprots	O43684 O43685 B2R6E7 A6NJ42 D3DRE9
Accessions	AAL17976 EAW49284 EAW49285 EAW49286 EAW49287 O43684 AF047472 AAC28438 AF047473 AAC28439 AF053304 AAC06258 AF081496 AAC36307 AK226060 AK293255 BAG56787 AK307958 AK312546 BAG35444 BC005138 AAH05138 BC022438 AAH22438 BM989334 BP328027 BU932619 BX647392 DQ891852 ABM82778 DQ895042 ABM85968 NM_001007793 NP_001007794 NM_004725 NP_004716
Function	Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. {ECO:0000269|PubMed:10198256, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:18199686}.
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. {ECO:0000250}.
Top Pathways	Cell cycle, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Bub3 full length protein - ab139802 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

Human Bub3 peptide - ab13739 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

BUB3 Antibody Blocking Peptide - LS-E21447 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BUB3 Antibody Blocking Peptide - LS-E30350 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Bub3 Recombinant Protein - H00009184-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Bub3 Protein - NBP2-22719 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Bub3 Blocking Peptide - NBP1-76796PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Human BUB3 protein - orb168015 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

BUB3 peptide - orb218231 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg

BUB3 Blocking Peptide - 33R-6544 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BUB3 protein (His tag) - 80R-2633 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

BUB3 Blocking Peptide - abx063562 from Abbexa Category Peptide Species Human, Monkey

BUB3 (1-328, His-tag) - AR50753PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

BUB3 (1-328, His-tag) - AR50753PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

BUB3 - H00009184-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BUB3 - H00009184-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BUB3 Control Peptide - AP30173CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

BUB3, 1-328aa Human, His tag, E.coli - 01-P1929 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Bub3 Peptide - 4227P from ProSci Category Peptide Species Human

BUB3 fusion protein - Ag0167 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

BUB3 Human - PRPS-030 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

BUB3, 1-328aa Human, His tag, E.coli - GWB-PPST17 from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human BUB3, GST-tagged - BUB3-10336H from Creative Biomart Category Protein Source E.coli Species Human

BUB3 Blocking Peptide - CBP2368 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

BUB3 (H274) Peptide - BS2395P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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