| Gene Symbol |
SUV39H1
|
| Entrez Gene |
6839
|
| Alt Symbol |
H3-K9-HMTase 1, KMT1A, MG44, SUV39H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of variegation 3-9 homolog 1 (Drosophila)
|
| Other Description |
Su(var)3-9 homolog 1|histone H3-K9 methyltransferase 1|histone-lysine N-methyltransferase SUV39H1|histone-lysine N-methyltransferase, H3 lysine-9 specific 1|lysine N-methyltransferase 1A|position-effect variegation 3-9 homolog
|
| Swissprots |
Q6FHK6 Q53G60 B4DST0 O43463 B2R6E8
|
| Accessions |
CAA03483 EAW50756 EAW50757 O43463 AF019968 AAB92224 AF075109 AK223071 BAD96791 AK297566 BAG59958 AK298233 BAG60502 AK299900 BAG61742 AK312547 BAG35445 AW327567 BC006238 AAH06238 BG024540 CR541746 CAG46546 DQ892608 ABM83534 DQ895848 ABM86774 L08238 AAA59592 NM_001282166 NP_001269095 NM_003173 NP_003164
|
| Function |
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component
|
| Subcellular Location |
Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
|
| Top Pathways |
Lysine degradation
|
![Western Blot: KMT1A/SUV39H1 Overexpression Lysate (Adult Normal) [NBL1-16625] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KMT1A/SUV39H1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8277_KMT1A-SUV39H1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16625-img0002.jpg)