SUV39H1

Gene Symbol	SUV39H1
Entrez Gene	6839
Alt Symbol	H3-K9-HMTase 1, KMT1A, MG44, SUV39H
Species	Human
Gene Type	protein-coding
Description	suppressor of variegation 3-9 homolog 1 (Drosophila)
Other Description	Su(var)3-9 homolog 1|histone H3-K9 methyltransferase 1|histone-lysine N-methyltransferase SUV39H1|histone-lysine N-methyltransferase, H3 lysine-9 specific 1|lysine N-methyltransferase 1A|position-effect variegation 3-9 homolog
Swissprots	Q6FHK6 Q53G60 B4DST0 O43463 B2R6E8
Accessions	CAA03483 EAW50756 EAW50757 O43463 AF019968 AAB92224 AF075109 AK223071 BAD96791 AK297566 BAG59958 AK298233 BAG60502 AK299900 BAG61742 AK312547 BAG35445 AW327567 BC006238 AAH06238 BG024540 CR541746 CAG46546 DQ892608 ABM83534 DQ895848 ABM86774 L08238 AAA59592 NM_001282166 NP_001269095 NM_003173 NP_003164
Function	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component
Subcellular Location	Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SUV39H1-cDNA-Clone - DC01906 from Abgent, a WuXi AppTec company Prices $556.20 Sizes 10 µg Species Human Accession BC006238

SUV39H1 - MBS1272491 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC006238

Human SUV39H1 cDNA clone(NM_003173.2) - CDFH019010 from Creative Biomart Species Human Accession NM_003173.2

Human SUV39H1 ORF Clone(NM_003173.2) - CDCL177577 from Creative Biomart Species Human Accession NM_003173.2

Human SUV39H1 ORF Clone(NM_003173.2) - CDCR285055 from Creative Biomart Species Human Accession NM_003173.2

Human SUV39H1 ORF Clone(NM_003173.2) - CDCR285056 from Creative Biomart Species Human Accession NM_003173.2

Human SUV39H1 ORF Clone(NM_003173.2) - CDCR285057 from Creative Biomart Species Human Accession NM_003173.2

human SUV39H1 ORF clone - CDCH087714 from Creative Biomart Species Human Accession NM_003173

human SUV39H1 ORF clone - CDCH087715 from Creative Biomart Species Human Accession NM_003173

Human SUV39H1 Gene cDNA clone plasmid - HG11498-M from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11498-ACG from Sino Biological Species Human

Human SUV39H1 ORF Clone(NM_003173.2) - CDCR285055 from Creative biogene Species Human

Human SUV39H1 ORF Clone (BC006238) - CDCS411181 from Creative biogene Species Human Accession O43463

Human SUV39H1 gene - orb92072 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human SUV39H1 cDNA Clone(NM_003173.2) - CDFH019010 from Creative biogene Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11498-ACR from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11498-ANR from Sino Biological Species Human

Human SUV39H1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11498-ANG from Sino Biological Species Human

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