SUV39H1

Gene Symbol	SUV39H1
Entrez Gene	6839
Alt Symbol	H3-K9-HMTase 1, KMT1A, MG44, SUV39H
Species	Human
Gene Type	protein-coding
Description	suppressor of variegation 3-9 homolog 1 (Drosophila)
Other Description	Su(var)3-9 homolog 1|histone H3-K9 methyltransferase 1|histone-lysine N-methyltransferase SUV39H1|histone-lysine N-methyltransferase, H3 lysine-9 specific 1|lysine N-methyltransferase 1A|position-effect variegation 3-9 homolog
Swissprots	Q6FHK6 Q53G60 B4DST0 O43463 B2R6E8
Accessions	CAA03483 EAW50756 EAW50757 O43463 AF019968 AAB92224 AF075109 AK223071 BAD96791 AK297566 BAG59958 AK298233 BAG60502 AK299900 BAG61742 AK312547 BAG35445 AW327567 BC006238 AAH06238 BG024540 CR541746 CAG46546 DQ892608 ABM83534 DQ895848 ABM86774 L08238 AAA59592 NM_001282166 NP_001269095 NM_003173 NP_003164
Function	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component
Subcellular Location	Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human KMT1A / SUV39H1 full length protein - ab196397 from Abcam Category Protein Prices $858.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human KMT1A / SUV39H1 protein fragment - ab80289 from Abcam Category Protein Prices $239.00 Sizes 25 µg Source E. coli Species Human

SUV39H1 Antibody Blocking Peptide - LS-E2895 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUV39H1 Antibody Blocking Peptide - LS-E11380 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUV39H1 Antibody Blocking Peptide - LS-E11381 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KMT1A/SUV39H1 Partial Recombinant Protein - H00006839-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human KMT1A/SUV39H1 Protein - H00006839-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

SUV39H1-Antibody-N-term-Blocking-peptide - BP14022a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SUV39H1 / KMT1A - H00006839-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SUV39H1 / KMT1A - H00006839-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SUV39H1 / KMT1A - H00006839-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SUV39H1 fusion protein - ag0854 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SUV39H1 fusion protein - Ag21190 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

Recombinant SUV39H1 protein - 31339 from ActiveMotif Category Protein Prices $395.00 Sizes 25 µg Source E. coli Species Human

Recombinant Human SUV39H1, GST-tagged - SUV39H1-471H from Creative Biomart Category Protein Source E.Coli .

Recombinant Human Suppressor Of Variegation 3-9 Homolog 1 (Drosophila), GST-tagged - SUV39H1-4891H from Creative Biomart Category Protein Species Human

Recombinant Human SUV39H1 - SUV39H1-29906TH from Creative Biomart Category Protein Source E. coli

Recombinant Human SUV39H1, GST-tagged - SUV39H1-6968H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human SUV39H1 - SUV39H1-406H from Creative Biomart Category Protein Source Mammalian Cells Species Human

SUV39H1 protein-GST fusion - 009-001-T69 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

SUV39H1 protein-GST fusion - 009-001-T69S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human Histone-lysine N-methyltransferase SUV39H1(SUV39H1) - CSB-YP022972HU CSB-EP022972HU CSB-BP022972HU CSB-MP022972HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human SUV39H1 Protein, His-tagged - SUV39H1-208H from Creative Biomart Category Protein Source E.coli Species Human

SUV39H1 Antibody - SH-A16098 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

SUV39H1 antibody ( mAb ) , 100 ug - HM-AB2034 from Novatein Biosciences Prices $442.00 Sizes 100 µg

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