SUV39H1
| Gene Symbol | SUV39H1 |
|---|---|
| Entrez Gene | 6839 |
| Alt Symbol | H3-K9-HMTase 1, KMT1A, MG44, SUV39H |
| Species | Human |
| Gene Type | protein-coding |
| Description | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| Other Description | Su(var)3-9 homolog 1|histone H3-K9 methyltransferase 1|histone-lysine N-methyltransferase SUV39H1|histone-lysine N-methyltransferase, H3 lysine-9 specific 1|lysine N-methyltransferase 1A|position-effect variegation 3-9 homolog |
| Swissprots | Q6FHK6 Q53G60 B4DST0 O43463 B2R6E8 |
| Accessions | CAA03483 EAW50756 EAW50757 O43463 AF019968 AAB92224 AF075109 AK223071 BAD96791 AK297566 BAG59958 AK298233 BAG60502 AK299900 BAG61742 AK312547 BAG35445 AW327567 BC006238 AAH06238 BG024540 CR541746 CAG46546 DQ892608 ABM83534 DQ895848 ABM86774 L08238 AAA59592 NM_001282166 NP_001269095 NM_003173 NP_003164 |
| Function | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component |
| Subcellular Location | Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin. |
| Top Pathways | Lysine degradation |
SUV39H1 CRISPR/Cas9 KO Plasmid (h) - sc-401717 from Santa Cruz Biotechnology
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SUV39H1 HDR Plasmid (h) - sc-401717-HDR from Santa Cruz Biotechnology
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SUV39H1 Double Nickase Plasmid (h) - sc-401717-NIC from Santa Cruz Biotechnology
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SUV39H1 Double Nickase Plasmid (h2) - sc-401717-NIC-2 from Santa Cruz Biotechnology
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SUV39H1 CRISPR Activation Plasmid (h) - sc-401717-ACT from Santa Cruz Biotechnology
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SUV39H1 CRISPR Activation Plasmid (h2) - sc-401717-ACT-2 from Santa Cruz Biotechnology
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SUV39H1 Lentiviral Activation Particles (h) - sc-401717-LAC from Santa Cruz Biotechnology
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SUV39H1 Lentiviral Activation Particles (h2) - sc-401717-LAC-2 from Santa Cruz Biotechnology
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SUV39H1 siRNA (h) - sc-38463 from Santa Cruz Biotechnology
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SUV39H1 shRNA Plasmid (h) - sc-38463-SH from Santa Cruz Biotechnology
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SUV39H1 shRNA (h) Lentiviral Particles - sc-38463-V from Santa Cruz Biotechnology
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KMT1A/SUV39H1 RNAi - H00006839-R01 from Novus Biologicals
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MISSION® esiRNA - EHU158181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20857 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20857 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09647 from Sigma-Aldrich
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SUV39H1 siRNA (Human) - CRH4677 from Cohesion Biosciences
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SUV39H1 - MBS8207811 from MyBioSource
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shRNA set against Human SUV39H1 (NM_003173.2) - SHH421184 from Creative biogene
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Human SUV39H1 siRNA - orb265179 from Biorbyt
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SUV39H1 shRNA Plasmid (Human) - CHH4677 from Cohesion Biosciences
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SUV39H1 miRNA 3'UTR clone - MiUTR1H-10085 from Creative biogene
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