| Gene Symbol | ATP2B3 |
|---|---|
| Entrez Gene | 492 |
| Alt Symbol | CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, Ca++ transporting, plasma membrane 3 |
| Other Description | cilia and flagella associated protein 39|plasma membrane calcium ATPase|plasma membrane calcium pump|plasma membrane calcium-transporting ATPase 3 |
| Swissprots | B7WNR8 B7WNY5 Q12995 Q16858 Q16720 |
| Accessions | EAW72858 EAW72859 EAW72860 Q16720 AK090838 AK094500 AK130194 BAC85302 AK307765 AK308705 BC047580 BC130009 AAI30010 BG739902 BM680649 BM695792 BM805938 BM986989 BQ878721 BU183973 BU790224 BU790521 DQ201779 ABG24243 U15689 AAA60986 U15690 AAA60987 U57971 AAB09762 U60414 AAB38530 XM_005274689 XP_005274746 XM_005274690 XP_005274747 XM_005274691 XP_005274748 XM_005274692 XP_005274749 XM_011531174 XP_011529476 XM_011531175 XP_011529477 XM_011531176 XP_011529478 XM_011531177 XP_011529479 NM_001001344 NP_001001344 NM_021949 NP_068768 |
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Highly expressed in the cerebellum, particulary in the presynaptic terminals of parallel fibers- Purkinje neurons. Isoform XE and isoform XB are the most abundant isoforms and are detected at low levels in brain and fetal skeletal muscle. The other isoforms are only found at lower levels and not in fetal tissues. {ECO:0000269|PubMed:22912398}. |
| Top Pathways | Calcium signaling pathway, Salivary secretion, Pancreatic secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway |