| Gene Symbol |
TWF1
|
| Entrez Gene |
5756
|
| Alt Symbol |
A6, PTK9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
twinfilin actin-binding protein 1
|
| Other Description |
A6 protein tyrosine kinase|PTK9 protein tyrosine kinase 9|protein A6|protein tyrosine kinase 9|twinfilin, actin-binding protein, homolog 1|twinfilin-1
|
| Swissprots |
Q86XL6 B3KXS6 Q8TCD3 Q59G07 Q6FHL6 Q6FHJ1 Q6NUK9 B4DLX9 Q12792 A8K5A8 Q5U0B1
|
| Accessions |
EAW57868 EAW57869 EAW57870 Q12792 AB209302 BAD92539 AK127868 BAG54588 AK291223 BAF83912 AK297206 BAG59691 BC022344 AAH22344 BC022491 BC043148 AAH43148 BC068548 AAH68548 BT019691 AAV38497 CR541736 CAG46536 CR541761 CAG46561 EU832120 ACE87470 EU832214 ACE86784 U02680 AAC50062 NM_001242397 NP_001229326 NM_002822 NP_002813 NR_073472 NR_073473 NM_198974
|
| Function |
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. {ECO:0000269|PubMed:7507208}.
|
![Western Blot: PTK9 Overexpression Lysate (Adult Normal) [NBL1-17458] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PTK9.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4539_PTK9%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17458-img0002.jpg)