PFN1

Gene Symbol PFN1
Entrez Gene 5216
Alt Symbol ALS18
Species Human
Gene Type protein-coding
Description profilin 1
Other Description epididymis tissue protein Li 184a|profilin I|profilin-1
Swissprots Q53Y44 P07737
Accessions EAW90381 EAW90382 EAW90383 EAW90384 P07737 AA358044 AK312168 BAG35102 AL525538 BC002475 AAH02475 BC006768 AAH06768 BC013439 AAH13439 BC015164 AAH15164 BC057828 AAH57828 BM850671 BT007001 AAP35647 CR407670 CAG28598 D28377 BAA05743 DQ891100 ABM82026 DQ894282 ABM85208 GU727630 ADU87632 J03191 AAA36486 NM_005022 NP_005013
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}.
Subcellular Location Cytoplasm, cytoskeleton.
Tissue Specificity Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}.
Top Pathways Salmonella infection, Rap1 signaling pathway, Regulation of actin cytoskeleton

Profilin-1 Antibody - 3237 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using Profilin-1 Antibody.

Profilin-1 (C56B8) Rabbit mAb - 3246 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C56B8
Western blot analysis of extracts from various cell types using Profilin-1 (C56B8) Rabbit mAb.

Profilin-1 (B-10) - sc-137235 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Profilin-1 (B-10): sc-137235. Western blot analysis of Profilin-1 expression in non-transfected: sc-110760 (A), human Profilin-1 transfected: sc-111317 (B) 293 whole cell lysates and human platelet extract (C).

Profilin-1 (C-15) - sc-30522 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Profilin-1 (C-15): sc-30522. Western blot analysis of Profilin-1 expression in human Profilin-1 transfected: sc-111317 (A) and non-transfected: sc-110760 (B) 293 whole cell lysates.

Profilin-1 (H-4) - sc-137236 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Profilin-1 (H-4): sc-137236. Western blot analysis of Profilin-1 expression in Hep G2 (A), JAR (B), NIH/3T3 (C) and KNRK (D) whole cell lysates.

Profilin-1 (48) - sc-136432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Profilin-1 (48): sc-136432. Western blot analysis of Profilin-1 expression in Jurkat whole cell lysate.

Profilin-1 (C-2) - sc-166191 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Profilin-1 (C-2): sc-166191. Western blot analysis of Profilin-1 expression in human platelet extract (A) and KNRK whole cell lysate (B).

Profilin-1 (N-20) - sc-18346 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Profilin-1 (N-20): sc-18346. Western blot analysis of Profilin-1 expression in human Profilin-1 transfected: sc-111317 (A) and non-transfected: sc-110760 (B) 293 whole cell lysates.

Profilin-1 (V-17) - sc-30521 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Profilin-1 (V-17): sc-30521. Western blot analysis of Profilin-1 expression in non-transfected: sc-110760 (A) and human Profilin-1 transfected: sc-110512 (B) 293 whole cell lysates.

Profilin-1/2 (FL-140) - sc-25788 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Profilin-1/2 (FL-140): sc-25788. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.

Anti-Profilin 1 antibody - ab180830 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Profilin 1 antibody (ab180830) at 1/500 dilutionLane 1 : COS7 cell lysateLane 2 : HT-29 cell lysateLane 3 : PC12 cell lysateLane 4 : Jurkat cell lysate

Anti-Profilin 1 antibody - ab182774 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Profilin 1 antibody (ab182774) at 1/200 dilutionLane 1 : HeLa cell lysateLane 2 : HT-29 cell lysateLane 3 : A549 cell lysateLysates/proteins at 40 µg per lane.SecondaryGoat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution

Anti-Profilin 1 antibody - ab172070 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Profilin 1 antibody (ab172070) at 1 µg/mlLane 1 : Profilin 1 transfected lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.

Anti-Profilin 1 antibody [1D5] - ab118984 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D5
All lanes : Anti-Profilin 1 antibody [1D5] (ab118984) at 1/1000 dilutionLane 1 : HepG2 cell extractLane 2 : HeLa cell lysateLane 3 : HT29 cell extractLane 4 : A549 cell extractLane 5 : COS7 cell extractLane 6 : Jurkat cell extractLane 7 : MDCK cell extractLane 8 : PC12 cell extractLane 9 : MCF7 cell extractLysates/proteins at 35 µg per lane.

Anti-Profilin 1 antibody [EPR6303] - ab133529 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6303
All lanes : Anti-Profilin 1 antibody [EPR6303] (ab133529) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : JAR cell lysateLane 3 : HepG2 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.

Anti-Profilin 1 antibody [EPR6304] - ab124904 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6304
Overlay histogram showing HeLa cells stained with ab124904 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab124904, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-PFN1 / Profilin 1 Antibody IHC-plus™ - LS-B292 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PFN1 / Profilin 1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B292 concentration 2.5 ug/ml.

Anti-PFN1 / Profilin 1 Antibody - LS-C89299 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PFN1 / Profilin 1 Antibody (C-Terminus, Biotin) - LS-C142710 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PFN1 / Profilin 1 Antibody (C-Terminus, DY650) - LS-C142711 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PFN1 / Profilin 1 Antibody (C-Terminus, DY488) - LS-C142712 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PFN1 / Profilin 1 Antibody (C-Terminus, HRP) - LS-C142713 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PFN1 / Profilin 1 Antibody (C-Terminus, DY550) - LS-C142714 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PFN1 / Profilin 1 Antibody (clone 2H11) - LS-C193430 from LifeSpan Bioscience

Prices $445.00
Sizes 5 ml
Host Mouse
Clonality Monoclonal
Clone 2H11

Anti-PFN1 / Profilin 1 Antibody (N-Terminus) - LS-C81198 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Fetal liver lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 10-20%.
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