| Gene Symbol |
CORO1A
|
| Entrez Gene |
11151
|
| Alt Symbol |
CLABP, CLIPINA, HCORO1, IMD8, TACO, p57
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coronin, actin binding protein, 1A
|
| Other Description |
clipin-A|coronin-1|coronin-1A|coronin-like protein A|coronin-like protein p57|tryptophan aspartate-containing coat protein
|
| Swissprots |
B2RBL1 P31146 Q2YD73
|
| Accessions |
EAW79906 EAW79907 EAW79908 EAW79909 EAW79910 P31146 AB209221 BAD92458 AF495470 AAM18516 AK096332 AK097964 AK123401 BAC85606 AK296207 BAG58933 AK314714 BAG37258 BC110374 AAI10375 BC126385 AAI26386 BC126387 AAI26388 CD623635 D44497 BAA07940 DA256300 DC408372 EU446773 ABZ92302 GQ214031 HQ258407 ADR83161 U34690 AAA77058 X89109 CAA61482 XM_011545714 XP_011544016 NM_001193333 NP_001180262 NM_007074 NP_009005
|
| Function |
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. {ECO:0000269|PubMed:10338208}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
|
| Top Pathways |
Phagosome, Tuberculosis
|
![Western Blot: Coronin-1a Overexpression Lysate (Adult Normal) [NBL1-09395] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Coronin-1a.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/942_Coronin-1a%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09395-img0002.jpg)