| Gene Symbol | HLA-DPA1 |
|---|---|
| Entrez Gene | 3113 |
| Alt Symbol | DP(W3), DP(W4), HLA-DP1A, HLADP, HLASB, PLT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | major histocompatibility complex, class II, DP alpha 1 |
| Other Description | HLA class II histocompatibility antigen, DP alpha 1 chain|HLA-SB alpha chain|MHC class II DP3-alpha|MHC class II HLA-DPA1 antigen|MHC class II antigen|Primed lymphocyte test-1 |
| Swissprots | Q5STP1 Q9XS10 O46883 A9YWH7 Q5EY03 O19722 B9UKH4 Q2Q061 P20036 Q9BCQ1 P79554 Q6DQK4 P01905 Q9TPX3 Q2Q060 |
| Accessions | AAA59786 AAB97110 AAC61669 AAC64233 AAC72845 AAD39684 AAD39685 AAD42927 AAD42928 AAD47826 AAF00051 AAK27152 AAQ84179 AAQ84180 AAQ84181 AAQ84182 AAQ84183 AAQ84184 AAQ84185 AAQ84186 AAQ84187 AAQ84188 AAQ84189 AAQ84190 AAQ84191 AAQ84192 AAQ84193 AAQ84194 AAQ84195 AAQ84196 AAQ84197 AAQ84198 AAQ84199 AAQ84200 AAQ84201 AAQ84202 AAQ84203 AAQ84204 AAQ84205 AAQ84206 AAQ84207 AAQ84208 AAQ84209 AAR01827 AAR01829 AAR01831 AAR01833 AAR01835 AAR01837 AAR01839 AAR01841 AAR01843 AAR01845 AAR01847 AAR01849 AAR01851 AAR01853 AAR01855 AAR01857 AAR01859 AAR01861 AAR01863 AAR01865 AAR01867 AAR01869 AAR01871 AAT39912 AAT39913 AAT39914 AAT39915 AAT39916 AAT67468 AAT92096 AAT92097 ABB88406 ABB88407 ACH88749 AFD18265 AGK38321 AHW47932 AHW47949 AHW47966 AHW47983 CAA26148 CAA26887 CCH26301 CEK46667 EAX03669 EAX03670 EAX03671 P20036 AB209058 BAD92295 AK292709 BAF85398 BC009956 AAH09956 BI553587 BP338039 BU687966 CD516536 DQ893463 ABM84389 DQ896324 ABM87323 M27487 AAA63220 X00457 CAA25143 XM_011514559 XP_011512861 XM_011546308 XP_011544610 XM_011547241 XP_011545543 XM_011547644 XP_011545946 XM_011547875 XP_011546177 XM_011548044 XP_011546346 XM_011548232 XP_011546534 XM_011548424 XP_011546726 NM_001242524 NP_001229453 NM_001242525 NP_001229454 NM_033554 NP_291032 |
| Function | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Top Pathways | Inflammatory bowel disease (IBD), HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection |