| Gene Symbol | ACSL3 |
|---|---|
| Entrez Gene | 2181 |
| Alt Symbol | ACS3, FACL3, PRO2194 |
| Species | Human |
| Gene Type | protein-coding |
| Description | acyl-CoA synthetase long-chain family member 3 |
| Other Description | LACS 3|fatty-acid-Coenzyme A ligase, long-chain 3|lignoceroyl-CoA synthase|long-chain acyl-CoA synthetase 3|long-chain-fatty-acid--CoA ligase 3 |
| Swissprots | Q8IUM9 Q60I92 O95573 |
| Accessions | BAB72139 CBF65064 CBU89935 EAW70807 EAW70808 EAW70809 O95573 AB061712 BAB72074 AF116690 AAF71110 AI378485 AK001471 BAG50918 AK023191 BAG51167 AK314621 BAG37187 BC012066 BC032144 AAH32144 BC041692 AAH41692 BF679686 BG772246 BM971377 BQ435549 BX472576 D89053 BAA37142 N44998 XR_922889 NM_004457 NP_004448 NM_203372 NP_976251 |
| Function | Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). {ECO:0000250, ECO:0000269|PubMed:18003621}. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. |
| Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation |