ATL1
| Gene Symbol | ATL1 |
|---|---|
| Entrez Gene | 51062 |
| Alt Symbol | AD-FSP, FSP1, GBP3, HSN1D, SPG3, SPG3A, atlastin1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | atlastin GTPase 1 |
| Other Description | GBP-3|GTP-binding protein 3|atlastin-1|brain-specific GTP-binding protein|guanine nucleotide-binding protein 3|guanylate-binding protein 3|hGBP3|spastic paraplegia 3 protein A |
| Swissprots | A6NND5 O95890 Q8WXF7 Q69YH7 Q96FK0 A8K2C0 G5E9T1 |
| Accessions | CAH25961 EAW65705 EAW65706 EAW65707 EAW65708 EAW65709 Q8WXF7 AF131801 AAD20047 AF444143 AAL37898 AK223436 BAD97156 AK290185 BAF82874 AK312518 AL833591 CAH10392 AW674605 AY032844 AAK51160 BC010708 AAH10708 BG704589 BI601372 CR457153 CAG33434 DA088230 DA397302 R61338 NM_001127713 NP_001121185 NM_015915 NP_056999 NM_181598 NP_853629 |
| Function | GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:21220294, ECO:0000269|PubMed:23334294}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, axon {ECO:0000250}. |
| Tissue Specificity | Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level). {ECO:0000269|PubMed:14506257, ECO:0000269|PubMed:17321752, ECO:0000269|PubMed:18270207}. |
Atlastin CRISPR/Cas9 KO Plasmid (h) - sc-403547 from Santa Cruz Biotechnology
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Atlastin HDR Plasmid (h) - sc-403547-HDR from Santa Cruz Biotechnology
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Atlastin Double Nickase Plasmid (h) - sc-403547-NIC from Santa Cruz Biotechnology
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Atlastin Double Nickase Plasmid (h2) - sc-403547-NIC-2 from Santa Cruz Biotechnology
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Atlastin CRISPR Activation Plasmid (h) - sc-403547-ACT from Santa Cruz Biotechnology
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Atlastin CRISPR Activation Plasmid (h2) - sc-403547-ACT-2 from Santa Cruz Biotechnology
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Atlastin Lentiviral Activation Particles (h) - sc-403547-LAC from Santa Cruz Biotechnology
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Atlastin Lentiviral Activation Particles (h2) - sc-403547-LAC-2 from Santa Cruz Biotechnology
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Atlastin siRNA (h) - sc-60225 from Santa Cruz Biotechnology
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Atlastin shRNA Plasmid (h) - sc-60225-SH from Santa Cruz Biotechnology
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Atlastin shRNA (h) Lentiviral Particles - sc-60225-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU092861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3660 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3660 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02580 from Sigma-Aldrich
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ATL1 siRNA (Human) - CRH9486 from Cohesion Biosciences
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SPG3A RNAi - H00051062-R04 from Novus Biologicals
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ATL1 - MBS827384 from MyBioSource
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shRNA set against Human ATL1 (NM_181598.3) - SHH242246 from Creative biogene
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ATL1 shRNA Plasmid (Human) - CHH9486 from Cohesion Biosciences
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ATL1 miRNA 3'UTR clone - MiUTR3H-08451 from Creative biogene
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ATL1 miRNA 3'UTR clone - MiUTR3H-08452 from Creative biogene
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ATL1 miRNA 3'UTR clone - MiUTR3H-08453 from Creative biogene
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