Gene Symbol | PLD6 |
---|---|
Entrez Gene | 201164 |
Alt Symbol | ZUC |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase D family, member 6 |
Other Description | PLD 6|choline phosphatase 6|mitoPLD|mitochondrial cardiolipin hydrolase|mitochondrial phospholipase|phosphatidylcholine-hydrolyzing phospholipase D6|phospholipase D6|protein zucchini homolog |
Swissprots | Q8N2A8 Q8N5Y1 |
Accessions | EAW55718 Q8N2A8 AK090899 BAC03541 AK098419 BAC05303 AK295282 BAG58266 BC031263 AAH31263 DC326979 NM_178836 NP_849158 |
Function | Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that ca |
Subcellular Location | Mitochondrion outer membrane {ECO:0000269|PubMed:17028579}; Single-pass membrane protein {ECO:0000269|PubMed:17028579}. |
Tissue Specificity | Widely expressed. Expression is not limited to testis and ovary. {ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397847}. |
PLD6 (G-16) - sc-243817 from Santa Cruz Biotechnology
|
||||||||
Anti-PLD6 antibody - ab151059 from Abcam
|
||||||||
Anti-PLD6 antibody - C-terminal - ab177449 from Abcam
|
||||||||
Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, AP) - LS-C266506 from LifeSpan Bioscience
|
||||||||
Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, APC) - LS-C266507 from LifeSpan Bioscience
|
||||||||
Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, Biotin) - LS-C266508 from LifeSpan Bioscience
|
||||||||
Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, FITC) - LS-C266509 from LifeSpan Bioscience
|
||||||||
Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, Azide-free, HRP) - LS-C266510 from LifeSpan Bioscience
|
||||||||
Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, PE) - LS-C266511 from LifeSpan Bioscience
|
||||||||
Anti-PLD6 / Phospholipase D6 Antibody (aa132-162) - LS-C329985 from LifeSpan Bioscience
|
||||||||
Anti-PLD6 / Phospholipase D6 Antibody (aa125-154) - LS-C163785 from LifeSpan Bioscience
|
||||||||
PLD6 Antibody - NBP2-13771 from Novus Biologicals
|
||||||||
Anti-PLD6 antibody produced in rabbit - HPA049345 from Sigma-Aldrich
|
||||||||
ANTI-PLD6 (CENTER) antibody produced in rabbit - SAB1302104 from Sigma-Aldrich
|
||||||||
PLD6 Antibody - C-terminal region (ARP69458_P050) - ARP69458_P050 from Aviva Systems Biology
|
||||||||
PLD6-Antibody-Center - AP11286c from Abgent, a WuXi AppTec company
|
||||||||
PLD6 Antibody - middle region (OAAB07532) - OAAB07532 from Aviva Systems Biology
|
||||||||
PLD6 antibody - orb29254 from Biorbyt
|
||||||||
PLD6 (Center) antibody - AP53346PU-N from Acris Antibodies
|
||||||||
Rabbit Anti-Mouse PLD6 (Center) - 102-11031 from RayBiotech
|
||||||||
PLD6 antibody (Center) - STJ41510 from St John's Laboratory Ltd
|
||||||||
Anti-PLD6 (aa 150-252) polyclonal antibody - DPABH-03215 from Creative Diagnostics
|
||||||||
Anti-PLD6 (aa 132-162) polyclonal antibody - DPABH-08475 from Creative Diagnostics
|
||||||||
Anti-PLD6 (aa 188-237) polyclonal antibody - DPABH-12434 from Creative Diagnostics
|
||||||||
Anti-PLD6 monoclonal antibody - DCABH-201267 from Creative Diagnostics
|