PLD6

Gene Symbol PLD6
Entrez Gene 201164
Alt Symbol ZUC
Species Human
Gene Type protein-coding
Description phospholipase D family, member 6
Other Description PLD 6|choline phosphatase 6|mitoPLD|mitochondrial cardiolipin hydrolase|mitochondrial phospholipase|phosphatidylcholine-hydrolyzing phospholipase D6|phospholipase D6|protein zucchini homolog
Swissprots Q8N2A8 Q8N5Y1
Accessions EAW55718 Q8N2A8 AK090899 BAC03541 AK098419 BAC05303 AK295282 BAG58266 BC031263 AAH31263 DC326979 NM_178836 NP_849158
Function Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that ca
Subcellular Location Mitochondrion outer membrane {ECO:0000269|PubMed:17028579}; Single-pass membrane protein {ECO:0000269|PubMed:17028579}.
Tissue Specificity Widely expressed. Expression is not limited to testis and ovary. {ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397847}.

PLD6 (G-16) - sc-243817 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PLD6 antibody - ab151059 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling PLD6 with ab151059 at 1/10 dilution.

Anti-PLD6 antibody - C-terminal - ab177449 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PLD6 antibody - C-terminal (ab177449) at 1 µg/ml + Human fetal heart lysate at 10 µg

Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, AP) - LS-C266506 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, APC) - LS-C266507 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, Biotin) - LS-C266508 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, FITC) - LS-C266509 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, Azide-free, HRP) - LS-C266510 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLD6 / Phospholipase D6 Antibody (aa132-162, PE) - LS-C266511 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLD6 / Phospholipase D6 Antibody (aa132-162) - LS-C329985 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLD6 / Phospholipase D6 Antibody (aa125-154) - LS-C163785 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PLD6 Antibody western blot of mouse testis tissue lysates (35 ug/lane). The PLD6 antibody detected the PLD6 protein (arrow).

PLD6 Antibody - NBP2-13771 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PLD6 Antibody [NBP2-13771] Staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

Anti-PLD6 antibody produced in rabbit - HPA049345 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PLD6:<B>Cat. No. HPA049345</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

ANTI-PLD6 (CENTER) antibody produced in rabbit - SAB1302104 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PLD6 (Center): <B>Cat. No. SAB1302104 </B>: PLD6 Antibody (Center) western blot analysis in mouse testis tissue lysates (35 μg/lane).

PLD6 Antibody - C-terminal region (ARP69458_P050) - ARP69458_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLD6-Antibody-Center - AP11286c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from human ovary and mouse testis tissue lysates (from left to right), using PLD6 Antibody (Center)(Cat. #AP11286c). AP11286c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

PLD6 Antibody - middle region (OAAB07532) - OAAB07532 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PLD6 antibody - orb29254 from Biorbyt

Prices $187.00, $383.00
Sizes 80 μl (Trial size), 400 μl
Host Rabbit
Clonality Polyclonal
Western blot analysis of mouse testis tissue lysates (35ug/lane) using PLD6 antibody

PLD6 (Center) antibody - AP53346PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of PLD6 Antibody (Center) Cat.-No AP53346PU-N in mouse testis tissue lysates (35ug/lane). This demonstrates the PLD6 antibody detected the PLD6 protein (arrow).

Rabbit Anti-Mouse PLD6 (Center) - 102-11031 from RayBiotech

Host Rabbit
Western blot analysis of lysates from human ovary and mouse testis tissue lysates (from left to right), using PLD6 Antibody (Center)(Cat# 102-11031). 102-11031 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

PLD6 antibody (Center) - STJ41510 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB28958

Anti-PLD6 (aa 150-252) polyclonal antibody - DPABH-03215 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-PLD6 (aa 132-162) polyclonal antibody - DPABH-08475 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-PLD6 (aa 188-237) polyclonal antibody - DPABH-12434 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-PLD6 monoclonal antibody - DCABH-201267 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal
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