| Gene Symbol |
PLD6
|
| Entrez Gene |
201164
|
| Alt Symbol |
ZUC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase D family, member 6
|
| Other Description |
PLD 6|choline phosphatase 6|mitoPLD|mitochondrial cardiolipin hydrolase|mitochondrial phospholipase|phosphatidylcholine-hydrolyzing phospholipase D6|phospholipase D6|protein zucchini homolog
|
| Swissprots |
Q8N2A8 Q8N5Y1
|
| Accessions |
EAW55718 Q8N2A8 AK090899 BAC03541 AK098419 BAC05303 AK295282 BAG58266 BC031263 AAH31263 DC326979 NM_178836 NP_849158
|
| Function |
Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that ca
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000269|PubMed:17028579}; Single-pass membrane protein {ECO:0000269|PubMed:17028579}.
|
| Tissue Specificity |
Widely expressed. Expression is not limited to testis and ovary. {ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397847}.
|