PLD6

Gene Symbol	PLD6
Entrez Gene	201164
Alt Symbol	ZUC
Species	Human
Gene Type	protein-coding
Description	phospholipase D family, member 6
Other Description	PLD 6|choline phosphatase 6|mitoPLD|mitochondrial cardiolipin hydrolase|mitochondrial phospholipase|phosphatidylcholine-hydrolyzing phospholipase D6|phospholipase D6|protein zucchini homolog
Swissprots	Q8N2A8 Q8N5Y1
Accessions	EAW55718 Q8N2A8 AK090899 BAC03541 AK098419 BAC05303 AK295282 BAG58266 BC031263 AAH31263 DC326979 NM_178836 NP_849158
Function	Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that ca
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:17028579}; Single-pass membrane protein {ECO:0000269|PubMed:17028579}.
Tissue Specificity	Widely expressed. Expression is not limited to testis and ovary. {ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397847}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human PLD6 full length protein - ab165881 from Abcam Category Protein Source Wheat germ Species Human

PLD6 / Phospholipase D6 Antibody Blocking Peptide - LS-E892 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLD6 / Phospholipase D6 Blocking Peptide - LS-E24846 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PLD6 Protein - H00201164-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PLD6-Antibody-Center-Blocking-peptide - BP11286c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PLD6 - H00201164-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PLD6 fusion protein - ag18725 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PLD6 fusion protein - Ag19126 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PLD6 - PLD6-1612H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Mitochondrial cardiolipin hydrolase(PLD6) - CSB-YP836649HU CSB-EP836649HU CSB-BP836649HU CSB-MP836649HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Homo sapiens (Human) Mitochondrial cardiolipin hydrolase - CSB-EP836649HU from Cusabio Category Protein Source E.coli Species Human

PLD6 Recombinant Protein Antigen - NBP2-13771PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PLD6 Peptide, Human - M34GP11917H from Creative Peptides Category Peptide Source Synthetic. Species Human

PLD6 Recombinant Protein (OPCA03428) - OPCA03428 from Aviva Systems Biology Category Protein Prices $365.00 Sizes 50 µg Source Human

Human PLD6 protein - orb358684 from Biorbyt Category Protein Prices $298.00, $527.00, $995.00, $1,649.00, $2,601.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Recombinant Human Mitochondrial cardiolipin hydrolase(PLD6) - AP74344 from Signalway Antibody Category Protein Prices $155.00, $390.00, $665.00, $1,090.00, $1,835.00, $2,915.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Mitochondrial cardiolipin hydrolase, Recombinant Protein - MBS9423924 from MyBioSource Category Protein Prices $200.00, $380.00, $610.00, $960.00, $1,570.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg Source E Coli Species Human

Mitochondrial cardiolipin hydrolase , Recombinant Protein - MBS1326126 from MyBioSource Category Protein Prices $135.00, $255.00, $665.00, $1,000.00, $1,090.00, $1,230.00, $1,230.00, $1,535.00, $1,710.00, $2,000.00, $2,000.00 Sizes 10 µg (E-Coli), 50 µg (E-Coli), 200 µg (E-Coli), 50 µg (Baculovirus), 500 µg (E-Coli), 50 µg (Mammalian-Cell), 500 µg (Yeast), 100 µg (Baculovirus), 1 mg (E-Coli), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human Mitochondrial cardiolipin hydrolase (PLD6) - RPC23361 from Biomatik Category Protein Prices $276.00, $505.00, $2,491.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Human

PLD6 fusion protein - Ag25894 from Proteintech Group Category Protein Source E. coli -derived, PET30a Species Human

Recombinant Human PLD6 Protein (1-252 aa), His-SUMO-tagged - PLD6-1895V from Creative Biomart Category Protein Source E. coli Species Human

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