| Gene Symbol | PLD6 |
|---|---|
| Entrez Gene | 201164 |
| Alt Symbol | ZUC |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipase D family, member 6 |
| Other Description | PLD 6|choline phosphatase 6|mitoPLD|mitochondrial cardiolipin hydrolase|mitochondrial phospholipase|phosphatidylcholine-hydrolyzing phospholipase D6|phospholipase D6|protein zucchini homolog |
| Swissprots | Q8N2A8 Q8N5Y1 |
| Accessions | EAW55718 Q8N2A8 AK090899 BAC03541 AK098419 BAC05303 AK295282 BAG58266 BC031263 AAH31263 DC326979 NM_178836 NP_849158 |
| Function | Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that ca |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000269|PubMed:17028579}; Single-pass membrane protein {ECO:0000269|PubMed:17028579}. |
| Tissue Specificity | Widely expressed. Expression is not limited to testis and ovary. {ECO:0000269|PubMed:17028579, ECO:0000269|PubMed:21397847}. |
PLD6 CRISPR/Cas9 KO Plasmid (h) - sc-410373 from Santa Cruz Biotechnology
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PLD6 HDR Plasmid (h) - sc-410373-HDR from Santa Cruz Biotechnology
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PLD6 Double Nickase Plasmid (h) - sc-410373-NIC from Santa Cruz Biotechnology
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PLD6 Double Nickase Plasmid (h2) - sc-410373-NIC-2 from Santa Cruz Biotechnology
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PLD6 CRISPR Activation Plasmid (h) - sc-410373-ACT from Santa Cruz Biotechnology
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PLD6 CRISPR Activation Plasmid (h2) - sc-410373-ACT-2 from Santa Cruz Biotechnology
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PLD6 Lentiviral Activation Particles (h) - sc-410373-LAC from Santa Cruz Biotechnology
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PLD6 Lentiviral Activation Particles (h2) - sc-410373-LAC-2 from Santa Cruz Biotechnology
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PLD6 siRNA (h) - sc-93913 from Santa Cruz Biotechnology
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PLD6 shRNA Plasmid (h) - sc-93913-SH from Santa Cruz Biotechnology
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PLD6 shRNA (h) Lentiviral Particles - sc-93913-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU040081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16941 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13167 from Sigma-Aldrich
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PLD6 siRNA (Human) - CRJ6279 from Cohesion Biosciences
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shRNA set against Human PLD6 (NM_178836.3) - SHH377392 from Creative biogene
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Human PLD6 siRNA - orb276780 from Biorbyt
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PLD6 shRNA Plasmid (Human) - CHJ6279 from Cohesion Biosciences
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PLD6 miRNA 3'UTR clone - MiUTR3H-15344 from Creative biogene
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